Korean J Hematol 1997; 32(3):
Published online September 30, 1997
© The Korean Society of Hematology
융모성 림프구를 갖는 비장 림프종 1례
김명신, 이아원, 김용구, 한경자, 강창석, 심상인, 박성규, 김춘추, 김응국
가톨릭대학교 의과대학 임상병리학교실,
가톨릭대학교 의과대학 내과학교실
가톨릭대학교 의과대학 외과학교실
A Case of Splenic Lymphoma with Villous Lymphocytes
Splenic lymphoma with villlous lymphocytes(SLVL) is a B cell chronic lymphoproliferative disorder which affects predominantly elderly males. Most patients present with splenomegaly without lymphadenopathy and a lymphocytosis.
This report describes a case of SLVL in 66 year old male who complained abdominal discomfort and abdominal mass. The leukocyte count was 47.8±10 9/L with
89% atypical lymphocytes showing variable amout of moderately basophilic cytoplasm and unevenly distributed or polar cytoplasmic villi. The bone marrow was effaced with these neoplastic lymphocytes. The immunophenotype of the neoplastic B cells was CDl9(+), CD2O(+), CD22(+), CDllc(+), CD2(-), CD3(-), CD5(-), CDIO(-), CD25(-) and
CDl5(-). The cytogenetic findings exhibited 46,XY,del(3)(q24),del(10)(p12). The spleen was weighted 520g and had nodular infiltrates of neoplastic B cells in the region of the white pulp with minimal red pulp involvement.
Keywords Splenic lymphoma; Villous lymphocytes; B cell; Immunophenotype;
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Korean J Hematol 1997; 32(3): 459-464
Published online September 30, 1997
Copyright © The Korean Society of Hematology.
융모성 림프구를 갖는 비장 림프종 1례
김명신, 이아원, 김용구, 한경자, 강창석, 심상인, 박성규, 김춘추, 김응국
가톨릭대학교 의과대학 임상병리학교실,
가톨릭대학교 의과대학 내과학교실
가톨릭대학교 의과대학 외과학교실
A Case of Splenic Lymphoma with Villous Lymphocytes
Myung Shin Kim, Ah Won Lee, Yong goo Kim, Kyung Ja Han, Chang Suck Kang, Sang In Shim, Sung Kyu Park, Chun Choo Kim, Eung Guk Kim
Department of Clinical Pathology, Internal Medicine, Surgery, Catholic University College of Medicine, Seoul, Korea
Abstract
Splenic lymphoma with villlous lymphocytes(SLVL) is a B cell chronic lymphoproliferative disorder which affects predominantly elderly males. Most patients present with splenomegaly without lymphadenopathy and a lymphocytosis.
This report describes a case of SLVL in 66 year old male who complained abdominal discomfort and abdominal mass. The leukocyte count was 47.8±10 9/L with
89% atypical lymphocytes showing variable amout of moderately basophilic cytoplasm and unevenly distributed or polar cytoplasmic villi. The bone marrow was effaced with these neoplastic lymphocytes. The immunophenotype of the neoplastic B cells was CDl9(+), CD2O(+), CD22(+), CDllc(+), CD2(-), CD3(-), CD5(-), CDIO(-), CD25(-) and
CDl5(-). The cytogenetic findings exhibited 46,XY,del(3)(q24),del(10)(p12). The spleen was weighted 520g and had nodular infiltrates of neoplastic B cells in the region of the white pulp with minimal red pulp involvement.
Keywords: Splenic lymphoma, Villous lymphocytes, B cell, Immunophenotype,
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