Korean J Hematol 1997; 32(1):
Published online March 31, 1997
© The Korean Society of Hematology
Dapsone 다량 중독에 의한 급성 용혈성 빈혈 및 Methemoglobinemia 치료 1례
성낙현, 김영완, 허완재, 임채호, 김재삼, 백석기, 박경식, 이춘일
청주 리라병원 내과,
강릉의료원 내과
A Case of Acute Hemolytic Anemia and Methemoglobinemia Induced by Massive Dapsone Intoxication
Dapsone toxicity is evidenced by varying clinical pictures ranging from deep cyanosis in an otherwise alert normal appearing individual to restlessness, dyspnea, extensive
hemolytic anemia, methemoglobinemia, sulfhemoglobinemia and serious central nervous system dysfunction.
We experienced a case of acute massive dapsone intoxication in 34 years old man due to voluntary ingestion of 25g of this drug as a suicide attempt. A severe methemoglobinemia developed, accompanied by nausea, vomiting, intense cyanosis, headache, and dyspnea. Subsequently moderate hemolytic anemia observed. The patient recovered completely after intensive treatment with methylene blue, activated charcoal hemoperfusion, oral charcoal ingestion, steroid, and conservative treatment. Methylene blue was given by continuous intravenous infusion in order to avoid overdosage.
We herein report a case of the acute hemolytic anemia and severe methemoglobinemia induced by massive dapsone intoxication with a review of the literature.
Keywords Dapsone; Hemolytic anemia; Methemoglobinemia; Methylene blue;
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Korean J Hematol 1997; 32(1): 106-111
Published online March 31, 1997
Copyright © The Korean Society of Hematology.
Dapsone 다량 중독에 의한 급성 용혈성 빈혈 및 Methemoglobinemia 치료 1례
성낙현, 김영완, 허완재, 임채호, 김재삼, 백석기, 박경식, 이춘일
청주 리라병원 내과,
강릉의료원 내과
A Case of Acute Hemolytic Anemia and Methemoglobinemia Induced by Massive Dapsone Intoxication
Nag Hyun Seong, Young Wan Kim, Wan Jae Heo, Chai Ho Lim, Jae Sam Kim, Seok Kie Paek, Kyung Sik Park, Chun il Lee
Department of Internal Medicine, Lee, Rha Hospital, Cheong Ju, Korea
Kangnung Medicine Center, Kangnung, Korea
Abstract
Dapsone toxicity is evidenced by varying clinical pictures ranging from deep cyanosis in an otherwise alert normal appearing individual to restlessness, dyspnea, extensive
hemolytic anemia, methemoglobinemia, sulfhemoglobinemia and serious central nervous system dysfunction.
We experienced a case of acute massive dapsone intoxication in 34 years old man due to voluntary ingestion of 25g of this drug as a suicide attempt. A severe methemoglobinemia developed, accompanied by nausea, vomiting, intense cyanosis, headache, and dyspnea. Subsequently moderate hemolytic anemia observed. The patient recovered completely after intensive treatment with methylene blue, activated charcoal hemoperfusion, oral charcoal ingestion, steroid, and conservative treatment. Methylene blue was given by continuous intravenous infusion in order to avoid overdosage.
We herein report a case of the acute hemolytic anemia and severe methemoglobinemia induced by massive dapsone intoxication with a review of the literature.
Keywords: Dapsone, Hemolytic anemia, Methemoglobinemia, Methylene blue,
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