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Bone marrow biopsy specimens at the time of diagnosis (hematoxylin and eosin stain, ×400). Atypical megakaryocytes showing cloud-like nuclei with a high nucleusto-cytoplasm ratio
Clinicolaboratory course of the patient. a)Number of Ph+ cells/number of analyzed cells by chromosome analysis; b)Number of Ph+ cells/number of analyzed cells by fluorescence