Korean J Hematol 2003; 38(3):
Published online September 30, 2003
© The Korean Society of Hematology
WHO 분류에 따른 골수섬유화를 동반한 급성범골수증식증 1례
강소영, 박찬정, 서을주, 지현숙, 이규형
울산의대 서울아산병원 진단검사의학,
울산의대 서울아산병원 내과
A Case of Acute Panmyelosis with Myelofibrosis according to WHO Classification
A 61-year-old man developed a rapidly progressive disease with anemia, thrombocytopenia and large number of blasts (10%) in the peripheral blood. The bone marrow revealed hypercellular marrow with extensive fibrosis and proliferation of immature cells of trilineage. Immunophenotyping and chromosome study with the bone marrow aspirate showed myelobalsts with aberrant expression of CD19 and complex karyotype including structural abnormalities within chromosome 5 and 7. After induction chemotherapy with Ara-c and daunorubicin, the number of blasts in peripheral blood was increased and the bone marrow showed hypercellular marrow with immature cells of trilineage and fibrosis. Cases like this have been called acute myelofibrosis, acute myelosclerosis or acute myelodysplasia with myelofibrosis. Recently this rare disease with rapidly fatal course was categorized into ‘acute panmyelosis with myelofibrosis in acute myelogenous leukemia (AML) not otherwise categorized’ by WHO classification
Keywords Acute myelofibrosis; Acute panmyelosis with myelofibrosis; WHO classification
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Korean J Hematol 2003; 38(3): 195-199
Published online September 30, 2003
Copyright © The Korean Society of Hematology.
WHO 분류에 따른 골수섬유화를 동반한 급성범골수증식증 1례
강소영, 박찬정, 서을주, 지현숙, 이규형
울산의대 서울아산병원 진단검사의학,
울산의대 서울아산병원 내과
A Case of Acute Panmyelosis with Myelofibrosis according to WHO Classification
So Young Kang, Chan Jeoung Park, Eul Joo Suh, Gyu Hyung Lee, Hyun Sook Chi
Department of Laboratory Medicine, Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
Abstract
A 61-year-old man developed a rapidly progressive disease with anemia, thrombocytopenia and large number of blasts (10%) in the peripheral blood. The bone marrow revealed hypercellular marrow with extensive fibrosis and proliferation of immature cells of trilineage. Immunophenotyping and chromosome study with the bone marrow aspirate showed myelobalsts with aberrant expression of CD19 and complex karyotype including structural abnormalities within chromosome 5 and 7. After induction chemotherapy with Ara-c and daunorubicin, the number of blasts in peripheral blood was increased and the bone marrow showed hypercellular marrow with immature cells of trilineage and fibrosis. Cases like this have been called acute myelofibrosis, acute myelosclerosis or acute myelodysplasia with myelofibrosis. Recently this rare disease with rapidly fatal course was categorized into ‘acute panmyelosis with myelofibrosis in acute myelogenous leukemia (AML) not otherwise categorized’ by WHO classification
Keywords: Acute myelofibrosis, Acute panmyelosis with myelofibrosis, WHO classification
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