Korean J Hematol 2003; 38(3):
Published online September 30, 2003
© The Korean Society of Hematology
급성전골수구성백혈병에서 All-trans Retinoic Acid에 의해 발생한 Myositis 1례
고윤석, 김주상, 홍석인, 이석, 김유진, 박윤희, 김희제, 김동욱, 이종욱, 민우성, 김춘추
가톨릭대학교 의과대학 내과학교실, 조혈모세포이식센터
All-trans Retinoic Acid induced Myositis in a Patient with Acute Promyelocytic Leukemia
Acute promyelocytic leukemia (APL) is characterized by a specific chromosme translocation t(15:17), which fuses the promyelocytic leukemia (PML) gene to the retinoic acid receptor α (RAR α) gene, and by a unique response to the differentiating agent all-trans retinoic acid (ATRA). Although ATRA dose not exhibit the conventional side effects of anticancer agents, it has its own unique side effects including retionic acid syndrome, Sweet’s syndrome, and myositis. Muscular involvement associated with ATRA therapy in APL has been rarely reported. We report a case of isolated myositis induced by ATRA in the induction treatment of APL. ATRA-induced myositis has distinctive clinical features and radiologic findings that should allow its recognition in order to treat promptly with steroid therapy.
Keywords All-trans retinoic acid; Myositis; Acute promyelocytic leukemia
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Korean J Hematol 2003; 38(3): 191-194
Published online September 30, 2003
Copyright © The Korean Society of Hematology.
급성전골수구성백혈병에서 All-trans Retinoic Acid에 의해 발생한 Myositis 1례
고윤석, 김주상, 홍석인, 이석, 김유진, 박윤희, 김희제, 김동욱, 이종욱, 민우성, 김춘추
가톨릭대학교 의과대학 내과학교실, 조혈모세포이식센터
All-trans Retinoic Acid induced Myositis in a Patient with Acute Promyelocytic Leukemia
Yoon Seok Koh, Seok Lee, Yoo Jin Kim, Jusang Kim, Seok In Hong, Yoon Hee Park, Hee Je Kim, Dong Wook Kim, Jong Wook Lee, Woo Sung Min, Chun Choo Kim
Department of Internal Medicine, Catholic Hematopoietic Stem Cell Transplantation Center, College of Medicine, The Catholic University of Korea, Seoul, Korea
Catholic Hematopoietic Stem Cell Transplantation Center
Abstract
Acute promyelocytic leukemia (APL) is characterized by a specific chromosme translocation t(15:17), which fuses the promyelocytic leukemia (PML) gene to the retinoic acid receptor α (RAR α) gene, and by a unique response to the differentiating agent all-trans retinoic acid (ATRA). Although ATRA dose not exhibit the conventional side effects of anticancer agents, it has its own unique side effects including retionic acid syndrome, Sweet’s syndrome, and myositis. Muscular involvement associated with ATRA therapy in APL has been rarely reported. We report a case of isolated myositis induced by ATRA in the induction treatment of APL. ATRA-induced myositis has distinctive clinical features and radiologic findings that should allow its recognition in order to treat promptly with steroid therapy.
Keywords: All-trans retinoic acid, Myositis, Acute promyelocytic leukemia
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