Blood Res 2017; 52(3):
Published online September 25, 2017
https://doi.org/10.5045/br.2017.52.3.212
© The Korean Society of Hematology
1Department of Pathology, Lady Hardinge Medical College, New Delhi, India.
2Department of Paediatrics, Lady Hardinge Medical College, New Delhi, India.
Correspondence to : Gunjan Mahajan, M.D. Department of Pathology, Lady Hardinge Medical College, Shaheed Bhagat Singh Marg, New Delhi-110001, India. dr.gunjan2003@gmail.com
Anemia of chronic disease (ACD) and iron deficiency anemia (IDA) are the two most prevalent forms of anemia having interrelated characteristics. Hepcidin, a newly introduced biomarker for assessment of iron status, is a homeostatic regulator of iron metabolism. We investigated the role of hepcidin and other conventional iron parameters to assess iron status among children with ACD and IDA. We also identified children with ACD who developed iron deficiency (ID).
The study was undertaken in anemic children with 30 cases each of ACD and IDA along with 30 age and sex-matched controls. The ACD cases were subdivided into pure ACD and ACD with coexistent ID. All cases were subjected to following tests: complete blood count with peripheral smear, serum C-reactive protein, serum interleukin-6, iron studies, serum soluble transferrin receptor (sTfR), and serum hepcidin.
The mean serum hepcidin concentration was significantly increased in pure ACD patients (143.85±42.76 ng/mL) as compared to those in IDA patients (6.01±2.83 ng/mL,
Hepcidin measurement can provide a useful tool for differentiating ACD from IDA and also help to identify an iron deficiency in ACD patients. This might aid in the appropriate selection of therapy for these patients.
Keywords Hepcidin, Anemia of chronic disease, Iron deficiency anemia, Children
Blood Res 2017; 52(3): 212-217
Published online September 25, 2017 https://doi.org/10.5045/br.2017.52.3.212
Copyright © The Korean Society of Hematology.
Gunjan Mahajan1*, Sunita Sharma1, Jagdish Chandra2, and Anita Nangia1
1Department of Pathology, Lady Hardinge Medical College, New Delhi, India.
2Department of Paediatrics, Lady Hardinge Medical College, New Delhi, India.
Correspondence to:Gunjan Mahajan, M.D. Department of Pathology, Lady Hardinge Medical College, Shaheed Bhagat Singh Marg, New Delhi-110001, India. dr.gunjan2003@gmail.com
Anemia of chronic disease (ACD) and iron deficiency anemia (IDA) are the two most prevalent forms of anemia having interrelated characteristics. Hepcidin, a newly introduced biomarker for assessment of iron status, is a homeostatic regulator of iron metabolism. We investigated the role of hepcidin and other conventional iron parameters to assess iron status among children with ACD and IDA. We also identified children with ACD who developed iron deficiency (ID).
The study was undertaken in anemic children with 30 cases each of ACD and IDA along with 30 age and sex-matched controls. The ACD cases were subdivided into pure ACD and ACD with coexistent ID. All cases were subjected to following tests: complete blood count with peripheral smear, serum C-reactive protein, serum interleukin-6, iron studies, serum soluble transferrin receptor (sTfR), and serum hepcidin.
The mean serum hepcidin concentration was significantly increased in pure ACD patients (143.85±42.76 ng/mL) as compared to those in IDA patients (6.01±2.83 ng/mL,
Hepcidin measurement can provide a useful tool for differentiating ACD from IDA and also help to identify an iron deficiency in ACD patients. This might aid in the appropriate selection of therapy for these patients.
Keywords: Hepcidin, Anemia of chronic disease, Iron deficiency anemia, Children
Correlation between ferritin and hepcidin concentrations in the pure ACD and IDA groups.
Correlation of IL-6 and serum hepcidin concentrations in patients with ACD.
Table 1 . Comparison of inflammatory markers and hematological parameters in pure ACD (A1), ACD with coexistent ID (A2), IDA, and controls..
Abbreviations: ACD, anemia of chronic disease; CRP, C-reactive protein; Hb, hemoglobin; IDA, iron deficiency anemia; IL, interleukin; MCH, mean cell hemoglobin; MCHC, mean cell hemoglobin concentration; MCV, mean cell volume; RBC, red blood cell; RDW, red cell distribution width; SD, standard deviation..
Table 2 . Comparison of iron status parameters in Pure ACD (A1), ACD with coexistent ID (A2), IDA, and controls..
Abbreviations: ACD, anemia of chronic disease; IDA, iron deficiency anemia; SD, standard deviation; sTfR, serum transferrin receptor; TIBC, total iron binding capacity..
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Correlation between ferritin and hepcidin concentrations in the pure ACD and IDA groups.
|@|~(^,^)~|@|Correlation of IL-6 and serum hepcidin concentrations in patients with ACD.