Korean J Hematol 2003; 38(3):
Published online September 30, 2003
© The Korean Society of Hematology
혈우병 B 환아에서 IX인자 투여 후 발생한 아나필락시스 1례
신수아, 김영대, 이항
한양대학교 의과대학 소아과학교실
A Case of Anaphylactic Response to Factor IX Replacement Therapy in Hemophilia B Patient
We report a first Korean case of anaphylactic response to factor IX replacement therapy in 22-month-old male hemophilia B patient. He was admitted to our hospital via emergency room due to anaphylactic response after factor IX infusion. Immediately after the infusion, he became dyspneic and cyanotic. The symptoms completely resolved after sleep. He represented same symptoms after next factor IX infusion, which completely resolved by the administration of oxygen. At the time of anaphylaxis, inhibitors of factor IX was demonstrated(8.8 Bethesda Unit). We planned him to treat with recombinant factor VII or diluted factor IX at bleeding episode.
Keywords Hemophilia B; Factor IX inhibitors; Anaphylaxis; Recombinant factor VII
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Korean J Hematol 2003; 38(3): 188-190
Published online September 30, 2003
Copyright © The Korean Society of Hematology.
혈우병 B 환아에서 IX인자 투여 후 발생한 아나필락시스 1례
신수아, 김영대, 이항
한양대학교 의과대학 소아과학교실
A Case of Anaphylactic Response to Factor IX Replacement Therapy in Hemophilia B Patient
Sj A Shin, Young Dai Kim, Hahng Lee
Department of Pediatrics, Hanyang University College of Medicine, Seoul, Korea
Abstract
We report a first Korean case of anaphylactic response to factor IX replacement therapy in 22-month-old male hemophilia B patient. He was admitted to our hospital via emergency room due to anaphylactic response after factor IX infusion. Immediately after the infusion, he became dyspneic and cyanotic. The symptoms completely resolved after sleep. He represented same symptoms after next factor IX infusion, which completely resolved by the administration of oxygen. At the time of anaphylaxis, inhibitors of factor IX was demonstrated(8.8 Bethesda Unit). We planned him to treat with recombinant factor VII or diluted factor IX at bleeding episode.
Keywords: Hemophilia B, Factor IX inhibitors, Anaphylaxis, Recombinant factor VII
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