Korean J Hematol 2002; 37(4):
Published online December 31, 2002
© The Korean Society of Hematology
일차성흉막삼출림프종
정승현, 장대영
한림대학교 의과대학 내과학교실
A Case of Primary Pleural Effusion Lymphoma
Primary effusion lymphoma (PEL) is a recently described subtype of malignant lymphoma which develops in association with human herpesvirus-8 (HHV-8) in human immunodeficiency virus (HIV)-infected patients. PEL presents predominantly as
lymphomatous effusion in the body cavities without a definite mass or lymphadenopathy. The malignant cell has large-cell morphology with null immunophenotype and B-cell genotype. We describe an unusual case of HIV negative HHV-8 negative PEL patient. A 48-year-old man presented with symptoms of right lower chest pain and fatigue for 3 months. Chest radiography and CT scan showed right pleural effusion and pleural thickening and no evidence of lymphadenopathy. Examination of the pleural fluid revealed
lympho-dominant exudate and the results of all cultures were negative. A malignant lymphoma of diffuse large B-cell type was confirmed by pleural biopsy. The results of serologic studies for HIV and PCR of HHV- 8 using pleura fluid and tissue were all negative.
Keywords Primary effusion lymphoma; Human herpesvirus-8; Human immunodeficiency virus;
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Korean J Hematol 2002; 37(4): 297-301
Published online December 31, 2002
Copyright © The Korean Society of Hematology.
일차성흉막삼출림프종
정승현, 장대영
한림대학교 의과대학 내과학교실
A Case of Primary Pleural Effusion Lymphoma
Seung Hyun Jung, Dae Young Zang
Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea
Abstract
Primary effusion lymphoma (PEL) is a recently described subtype of malignant lymphoma which develops in association with human herpesvirus-8 (HHV-8) in human immunodeficiency virus (HIV)-infected patients. PEL presents predominantly as
lymphomatous effusion in the body cavities without a definite mass or lymphadenopathy. The malignant cell has large-cell morphology with null immunophenotype and B-cell genotype. We describe an unusual case of HIV negative HHV-8 negative PEL patient. A 48-year-old man presented with symptoms of right lower chest pain and fatigue for 3 months. Chest radiography and CT scan showed right pleural effusion and pleural thickening and no evidence of lymphadenopathy. Examination of the pleural fluid revealed
lympho-dominant exudate and the results of all cultures were negative. A malignant lymphoma of diffuse large B-cell type was confirmed by pleural biopsy. The results of serologic studies for HIV and PCR of HHV- 8 using pleura fluid and tissue were all negative.
Keywords: Primary effusion lymphoma, Human herpesvirus-8, Human immunodeficiency virus,
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