Korean J Hematol 2002; 37(4):
Published online December 31, 2002
© The Korean Society of Hematology
2-Chlorodeoxyadenosine에 의해 완전관해가 유도된 모발상세포백혈병 3례
정대영, 이석, 김유진, 박윤희, 곽승기, 이혜정, 김희제, 김동욱, 이종욱, 민우성, 김춘추
가톨릭대학교 의과대학 조혈모세포이식센터,
가톨릭대학교 의과대학 내과학교실
Hairy Cell Leukemia Treated with 2-Chlorodeoxyadenosine
Hairy cell leukemia (HCL) is an uncommon chronic B-cell lymphoproliferative disorder characterized by cytopenia, splenomegaly and mononuclear cells displaying cytoplasmic projections. Diagnosis is based on the distinctive hairy cell morphology and immunological profile. In the last 10 to 15 years the prognosis of patients with HCL has improved considerably following the use of purine analogues such as deoxycoformycin and 2-chlorodeoxyadenosine (2-CdA). We report 3 patients with HCL who were treated with 2-CdA at a daily dosage of 0.1㎎/㎏ by continuous intravenous infusion for 7 days. After 1 or 2 courses of treatment, all patients achieved complete remission and are still alive in disease-free status.
Keywords Hairy cell leukemia; 2-chlorodeoxyadenosine; complete remission;
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Korean J Hematol 2002; 37(4): 292-296
Published online December 31, 2002
Copyright © The Korean Society of Hematology.
2-Chlorodeoxyadenosine에 의해 완전관해가 유도된 모발상세포백혈병 3례
정대영, 이석, 김유진, 박윤희, 곽승기, 이혜정, 김희제, 김동욱, 이종욱, 민우성, 김춘추
가톨릭대학교 의과대학 조혈모세포이식센터,
가톨릭대학교 의과대학 내과학교실
Hairy Cell Leukemia Treated with 2-Chlorodeoxyadenosine
Dae Young Cheung, Seok Lee, Yoo Jin Kim, Yoon Hee Park, Seung Ki Kwok, Hye Jung Lee, Hee Je Kim, Dong Wook Kim, Jong Wook Lee, Woo Sung Min, Chun Choo Kim
Department of Internal Medicine, Catholic Hematopoietic Stem Cell Transplantation Center, College of Medicine, The Catholic University of Korea, Seoul, Korea
Abstract
Hairy cell leukemia (HCL) is an uncommon chronic B-cell lymphoproliferative disorder characterized by cytopenia, splenomegaly and mononuclear cells displaying cytoplasmic projections. Diagnosis is based on the distinctive hairy cell morphology and immunological profile. In the last 10 to 15 years the prognosis of patients with HCL has improved considerably following the use of purine analogues such as deoxycoformycin and 2-chlorodeoxyadenosine (2-CdA). We report 3 patients with HCL who were treated with 2-CdA at a daily dosage of 0.1㎎/㎏ by continuous intravenous infusion for 7 days. After 1 or 2 courses of treatment, all patients achieved complete remission and are still alive in disease-free status.
Keywords: Hairy cell leukemia, 2-chlorodeoxyadenosine, complete remission,
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