Korean J Hematol 1995; 30(2):

Published online June 30, 1995

© The Korean Society of Hematology

한국의 악성 림프종에 관한 통계적 관찰

한지숙, 고윤웅, 민유홍, 김노경, 김동집, 김민철, 김병수, 김삼용, 김상희, 김준석, 박병채, 박승철, 박재후, 박희숙, 서창인, 선덕재, 송홍석, 심영학, 오도연, 이경식, 이규보, 이석, 이순남, 이승태, 이종화, 전춘해, 정현철, 조경삼, 조군제, 진춘조, 최일영, 최진혁, 현명수

대한혈액학회

Statistical Analysis of Malignant Lymphoma in Korea

J S Hahn, Y W Ko, Y H Min, N K Kim, D J Kim, M C Kim, B S Kim, S Y Kim, S H Kim, J S Kim, B C Park, S C Park, J H Park, H S Park, C I Suh, D J Sun, H S Song, Y H Shim, D Y Oh, K S Lee, K B Lee, S Lee, S N Lee, S T Lee, J H Lee, C H Chun, H C Jung, K S Cho, K J Cho, C J Jin, I Y Choi, J H Choi, M S Hyun

Korean Society of Hemotology

Abstract

Background: The disorder classified as malignant lymphoma are increasing in
frequency in Korea and there have been numerous advances in our understanding of the
pathophysiology of these disorders and in their treatment. There are considerable
geographic and ethnic differences in the incidence, age distribution, histopathologic types
of the malignant lymphoma.
Methods: We analyzed clinical findings of malignant lymphoma patients in Korea for
5 years. Sixteen hundred and fifty-three cases of the malignant lymphoma, which were
collected from the departments of internal medicine of 23 general hospitals and
university hospitals and department of pediatrics of one university hospital throughout
Korea, were summarized and reviewed. The data collected comprised of the cases for 5
years from January 1989 to December 1993.
Results : 1) There were 142 cases of Hodgkin disease(8.6%), and 1,511 cases of non-Hodgkin
lymphoma(91.4%) with 1 : 11 ratio.
2) The most common histopathologic type of Hodgkin disease was mixed
cellularity(54.2%), and that of non-Hodgkin lymphoma was diffuse, large cell type
(50.9%), respectively.
3) Peripheral lymphadenopathy was the most common presenting symptoms at the
time of first visit to the hospital, especially in Hodgkin disease.
4) High proportion of lymphomas(43.1% of total cases: 12.6% of Hodgkin disease and
46.3% of non-Hodgkin lymphoma) involved the extranodal sites. The most common site
was gastro-intestinal system(16.7%).
5) In treatment responses, the complete remission rate was 69.1% in Hodgkin disease
and 55.0% in non-Hodgkin lymphoma, respectively, and 13.8% of Hodgkin disease and
22.0% of non-Hodgkin lymphoma were relapsed. We observed the statistically significant
difference in survival duration between Hodgkin disease and non-Hodgkin lymphoma.
6) According to multivariate analysis, age, B-symptom, stage, LDH and number of
extranodal sites were the useful prognostic factors predicting survival.
Conclusion : The characteristics of malignant lymphoma in Korea differ from those in
the western countries with respect to the frequency of histopathologic pattern. The
epidemiologic studies are necessary for the clarification of these differences.

Keywords Malignant lymphoma, Hodgkin disease, Non-Hodgkin lymphoma, Histopathologic type, Prognostic factor

Article

Korean J Hematol 1995; 30(2): 197-214

Published online June 30, 1995

Copyright © The Korean Society of Hematology.

한국의 악성 림프종에 관한 통계적 관찰

한지숙, 고윤웅, 민유홍, 김노경, 김동집, 김민철, 김병수, 김삼용, 김상희, 김준석, 박병채, 박승철, 박재후, 박희숙, 서창인, 선덕재, 송홍석, 심영학, 오도연, 이경식, 이규보, 이석, 이순남, 이승태, 이종화, 전춘해, 정현철, 조경삼, 조군제, 진춘조, 최일영, 최진혁, 현명수

대한혈액학회

Statistical Analysis of Malignant Lymphoma in Korea

J S Hahn, Y W Ko, Y H Min, N K Kim, D J Kim, M C Kim, B S Kim, S Y Kim, S H Kim, J S Kim, B C Park, S C Park, J H Park, H S Park, C I Suh, D J Sun, H S Song, Y H Shim, D Y Oh, K S Lee, K B Lee, S Lee, S N Lee, S T Lee, J H Lee, C H Chun, H C Jung, K S Cho, K J Cho, C J Jin, I Y Choi, J H Choi, M S Hyun

Korean Society of Hemotology

Abstract

Background: The disorder classified as malignant lymphoma are increasing in
frequency in Korea and there have been numerous advances in our understanding of the
pathophysiology of these disorders and in their treatment. There are considerable
geographic and ethnic differences in the incidence, age distribution, histopathologic types
of the malignant lymphoma.
Methods: We analyzed clinical findings of malignant lymphoma patients in Korea for
5 years. Sixteen hundred and fifty-three cases of the malignant lymphoma, which were
collected from the departments of internal medicine of 23 general hospitals and
university hospitals and department of pediatrics of one university hospital throughout
Korea, were summarized and reviewed. The data collected comprised of the cases for 5
years from January 1989 to December 1993.
Results : 1) There were 142 cases of Hodgkin disease(8.6%), and 1,511 cases of non-Hodgkin
lymphoma(91.4%) with 1 : 11 ratio.
2) The most common histopathologic type of Hodgkin disease was mixed
cellularity(54.2%), and that of non-Hodgkin lymphoma was diffuse, large cell type
(50.9%), respectively.
3) Peripheral lymphadenopathy was the most common presenting symptoms at the
time of first visit to the hospital, especially in Hodgkin disease.
4) High proportion of lymphomas(43.1% of total cases: 12.6% of Hodgkin disease and
46.3% of non-Hodgkin lymphoma) involved the extranodal sites. The most common site
was gastro-intestinal system(16.7%).
5) In treatment responses, the complete remission rate was 69.1% in Hodgkin disease
and 55.0% in non-Hodgkin lymphoma, respectively, and 13.8% of Hodgkin disease and
22.0% of non-Hodgkin lymphoma were relapsed. We observed the statistically significant
difference in survival duration between Hodgkin disease and non-Hodgkin lymphoma.
6) According to multivariate analysis, age, B-symptom, stage, LDH and number of
extranodal sites were the useful prognostic factors predicting survival.
Conclusion : The characteristics of malignant lymphoma in Korea differ from those in
the western countries with respect to the frequency of histopathologic pattern. The
epidemiologic studies are necessary for the clarification of these differences.

Keywords: Malignant lymphoma, Hodgkin disease, Non-Hodgkin lymphoma, Histopathologic type, Prognostic factor

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