Korean J Hematol 1994; 29(2):
Published online June 30, 1994
© The Korean Society of Hematology
장미경, 김난희, 최경묵, 이진구, 남용진, 신상원, 김준석, 손보라, 이갑노
고려대학교 의과대학 내과학교실,
고려대학교 의과대학 병리학교실
Chronic neutrophilic leukemia is a very rare myeloproliferative disorder which is characterized by severe sustained mature neutrophilic leukocytosis in peripheral blood, hepatosplenomegaly, elevated leukocyte alkaline phosphatase, serum uric acid, serum vitamin B12 and the bleeding tendency despite normal platelet count and coagulation time, absence of philadelphia chromosome, and the absence of fever or
underlying infection or disease sufficient to mimic a leukemoid reaction.
We have experienced a 69 years old male patient with typical neutrophilic leukemia who complained a huge intramuscular hematoma due to bleeding tendency despite
normal finding of coagulation test. On admission, the peripheral blood examination showed severe neutrophilic leukocytosis with 88% neutrophil and rare immature form,
anemia with hemoglobin 95g/L but normal platelet count of 121×109/L and normal clotting time. Leukocyte alkaline phosphatase score was elevated and the cytogenetic
study showed normal karyotype.
Keywords Chronic neutrophilic leukemia; Bleeding tendency; Philadelphia chromosome;
Korean J Hematol 1994; 29(2): 223-228
Published online June 30, 1994
Copyright © The Korean Society of Hematology.
장미경, 김난희, 최경묵, 이진구, 남용진, 신상원, 김준석, 손보라, 이갑노
고려대학교 의과대학 내과학교실,
고려대학교 의과대학 병리학교실
Mi Kyung Chang, Nan Hee Kim, Kyung Muk Choi, Jin Goo Lee, Yong Jin Nam, Sang Won Shin, Jun Suk Kim, Bo Ra Son, Gap No Lee
Department of Internal Medicine, Clinical Pathology, College of Medicine, Korea University, Seoul, Korea
Chronic neutrophilic leukemia is a very rare myeloproliferative disorder which is characterized by severe sustained mature neutrophilic leukocytosis in peripheral blood, hepatosplenomegaly, elevated leukocyte alkaline phosphatase, serum uric acid, serum vitamin B12 and the bleeding tendency despite normal platelet count and coagulation time, absence of philadelphia chromosome, and the absence of fever or
underlying infection or disease sufficient to mimic a leukemoid reaction.
We have experienced a 69 years old male patient with typical neutrophilic leukemia who complained a huge intramuscular hematoma due to bleeding tendency despite
normal finding of coagulation test. On admission, the peripheral blood examination showed severe neutrophilic leukocytosis with 88% neutrophil and rare immature form,
anemia with hemoglobin 95g/L but normal platelet count of 121×109/L and normal clotting time. Leukocyte alkaline phosphatase score was elevated and the cytogenetic
study showed normal karyotype.
Keywords: Chronic neutrophilic leukemia, Bleeding tendency, Philadelphia chromosome,
Na Ran Hi Lee, Seock Ah Im, Kyung Eun Lee, Do Yeun Kim, Eun Mi Nam, Seong Eun Kim, So Hyeon Lee, Ji Eun Chang, Jee Eun Chang, Moon Sun Yeoum, Hae Jung Yeoum, Jung, Mi Kwon, Young, Ju Choi, Chu, Myoung Seong, Soon Nam Lee, Ju Young Seo, Hee, Jin Huh, Wha Soon Chung
Korean J Hematol 2001; 36(4): 359-363Kwang Hyeun Kim, One Young Kim, Cheol Hyeon Jo, Seung Oeuk Lee, Bong Han Yoon, Myung Weon Kang, Yeun Keun Lim, Hyang Sun Yeu, Meung Hee Lee
Korean J Hematol 1998; 33(3): 454-459Sollip Kim, Chan Jeong Park, Kyoo Hyung Lee, Seong soo Jang, Hyun Sook Chi, Eul Ju Seo
Korean J Hematol 2007; 42(2): 151-156