Korean J Hematol 1994; 29(2):

Published online June 30, 1994

© The Korean Society of Hematology

만성 호중구성 백혈병(CNL) 1례

장미경, 김난희, 최경묵, 이진구, 남용진, 신상원, 김준석, 손보라, 이갑노

고려대학교 의과대학 내과학교실,
고려대학교 의과대학 병리학교실

A Case of Chronic Neutrophilic Leukemia

Mi Kyung Chang, Nan Hee Kim, Kyung Muk Choi, Jin Goo Lee, Yong Jin Nam, Sang Won Shin, Jun Suk Kim, Bo Ra Son, Gap No Lee

Department of Internal Medicine, Clinical Pathology, College of Medicine, Korea University, Seoul, Korea

Abstract

Chronic neutrophilic leukemia is a very rare myeloproliferative disorder which is characterized by severe sustained mature neutrophilic leukocytosis in peripheral blood, hepatosplenomegaly, elevated leukocyte alkaline phosphatase, serum uric acid, serum vitamin B12 and the bleeding tendency despite normal platelet count and coagulation time, absence of philadelphia chromosome, and the absence of fever or
underlying infection or disease sufficient to mimic a leukemoid reaction.
We have experienced a 69 years old male patient with typical neutrophilic leukemia who complained a huge intramuscular hematoma due to bleeding tendency despite
normal finding of coagulation test. On admission, the peripheral blood examination showed severe neutrophilic leukocytosis with 88% neutrophil and rare immature form,
anemia with hemoglobin 95g/L but normal platelet count of 121×109/L and normal clotting time. Leukocyte alkaline phosphatase score was elevated and the cytogenetic
study showed normal karyotype.

Keywords Chronic neutrophilic leukemia; Bleeding tendency; Philadelphia chromosome;

Article

Korean J Hematol 1994; 29(2): 223-228

Published online June 30, 1994

Copyright © The Korean Society of Hematology.

만성 호중구성 백혈병(CNL) 1례

장미경, 김난희, 최경묵, 이진구, 남용진, 신상원, 김준석, 손보라, 이갑노

고려대학교 의과대학 내과학교실,
고려대학교 의과대학 병리학교실

A Case of Chronic Neutrophilic Leukemia

Mi Kyung Chang, Nan Hee Kim, Kyung Muk Choi, Jin Goo Lee, Yong Jin Nam, Sang Won Shin, Jun Suk Kim, Bo Ra Son, Gap No Lee

Department of Internal Medicine, Clinical Pathology, College of Medicine, Korea University, Seoul, Korea

Abstract

Chronic neutrophilic leukemia is a very rare myeloproliferative disorder which is characterized by severe sustained mature neutrophilic leukocytosis in peripheral blood, hepatosplenomegaly, elevated leukocyte alkaline phosphatase, serum uric acid, serum vitamin B12 and the bleeding tendency despite normal platelet count and coagulation time, absence of philadelphia chromosome, and the absence of fever or
underlying infection or disease sufficient to mimic a leukemoid reaction.
We have experienced a 69 years old male patient with typical neutrophilic leukemia who complained a huge intramuscular hematoma due to bleeding tendency despite
normal finding of coagulation test. On admission, the peripheral blood examination showed severe neutrophilic leukocytosis with 88% neutrophil and rare immature form,
anemia with hemoglobin 95g/L but normal platelet count of 121×109/L and normal clotting time. Leukocyte alkaline phosphatase score was elevated and the cytogenetic
study showed normal karyotype.

Keywords: Chronic neutrophilic leukemia, Bleeding tendency, Philadelphia chromosome,

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