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Blood Res 2022; 57(2):
Published online June 30, 2022
https://doi.org/10.5045/br.2022.2021173
© The Korean Society of Hematology
Chronic myeloid leukemia: a type of MPN
Correspondence to : Muhammad Ammar Samad, MBBS
Department of Medicine, Dow Medical College, Dow University of Health Sciences, Baba-e-Urdu Road, Saddar, Karachi 74200, Pakistan
E-mail: ammarsamad29@gmail.com
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
This review article classifies chronic myeloid leukemia (CML) based on cytogenetic analyses and different mutations detected in CML patients. The use of advanced technologies, such as karyotyping, fluorescent in situ hybridization, and comparative genomic hybridization, has allowed us to study CML in detail and observe the different biochemical changes that occur in different CML types. This review also highlights the different types of receptor and signaling pathway mutations that occur in CML.
Keywords Chronic myeloid leukemia, Cytogenetics, Philadelphia chromosome, Myeloproliferative neoplasms
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Review Article
Blood Res 2022; 57(2): 95-100
Published online June 30, 2022 https://doi.org/10.5045/br.2022.2021173
Copyright © The Korean Society of Hematology.
Chronic myeloid leukemia: a type of MPN
Muhammad Ammar Samad, Eman Mahboob, Hussain Mansoor
Department of Medicine, Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan
Correspondence to:Muhammad Ammar Samad, MBBS
Department of Medicine, Dow Medical College, Dow University of Health Sciences, Baba-e-Urdu Road, Saddar, Karachi 74200, Pakistan
E-mail: ammarsamad29@gmail.com
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
This review article classifies chronic myeloid leukemia (CML) based on cytogenetic analyses and different mutations detected in CML patients. The use of advanced technologies, such as karyotyping, fluorescent in situ hybridization, and comparative genomic hybridization, has allowed us to study CML in detail and observe the different biochemical changes that occur in different CML types. This review also highlights the different types of receptor and signaling pathway mutations that occur in CML.
Keywords: Chronic myeloid leukemia, Cytogenetics, Philadelphia chromosome, Myeloproliferative neoplasms
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