Blood Res 2021; 56(3):
Published online September 30, 2021
https://doi.org/10.5045/br.2021.2021059
© The Korean Society of Hematology
Correspondence to : Moeinadin Safavi, M.S., Molecular Pathology and Cytogenetics Division, Pathology Department, Children’s Medical Center, Tehran University of Medical Sciences, District 6, Tehran 1419733151, Iran, E-mail: moein.safavi@gmail.com
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
The patient was a 3-year-old boy with previous diagnosis of T cell ALL who underwent hematopoietic stem cell transplantation after complete remission. Three months after transplantation, he presented with massive plural effusion with more than 90% blasts with T cell phenotype on flow cytometry. Bone marrow aspiration also revealed 53% blasts (A). They were positive for CD1a, CD3, CD4, CD8, and tdt. Bone marrow cytogenetic study revealed t(11;14)(p13;q11) in twenty cells and an additional trisomy 8 in fifteen cells (B). T cell receptor genes are located on chromosomes 7q35, 7p14, and 14q11. Their translocations with chromosomes 1, 7, 9, 10, 11, 12, 14 are commonly seen in T cell ALL. Furthermore, t(11;14)(p13;q11) leads to fusion of LMO2-TRA or TRD which is seen in 5–10% of pediatric T cell ALL. A review of Mitelman database showed approximately 100 cases of T cell acute lymphoblastic leukemia with t(11;14)(p13;q11). The most common additional cytogenetic aberrations were deletion 6q and deletion 9p in approximately 12% of cases and then trisomy 8 and trisomy 17 in about 3% of cases. Although prognostic significance of this translocation has not been clearly determined yet, it was accompanied by an early relapse after hematopoietic stem cell transplantation in this patient.
Blood Res 2021; 56(3): 128-128
Published online September 30, 2021 https://doi.org/10.5045/br.2021.2021059
Copyright © The Korean Society of Hematology.
Moeinadin Safavi1, Alieh Safari Sharari2
1Molecular Pathology and Cytogenetics Division, Pathology Department, 2Pediatric Hematology and Oncology Department, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
Correspondence to:Moeinadin Safavi, M.S., Molecular Pathology and Cytogenetics Division, Pathology Department, Children’s Medical Center, Tehran University of Medical Sciences, District 6, Tehran 1419733151, Iran, E-mail: moein.safavi@gmail.com
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
The patient was a 3-year-old boy with previous diagnosis of T cell ALL who underwent hematopoietic stem cell transplantation after complete remission. Three months after transplantation, he presented with massive plural effusion with more than 90% blasts with T cell phenotype on flow cytometry. Bone marrow aspiration also revealed 53% blasts (A). They were positive for CD1a, CD3, CD4, CD8, and tdt. Bone marrow cytogenetic study revealed t(11;14)(p13;q11) in twenty cells and an additional trisomy 8 in fifteen cells (B). T cell receptor genes are located on chromosomes 7q35, 7p14, and 14q11. Their translocations with chromosomes 1, 7, 9, 10, 11, 12, 14 are commonly seen in T cell ALL. Furthermore, t(11;14)(p13;q11) leads to fusion of LMO2-TRA or TRD which is seen in 5–10% of pediatric T cell ALL. A review of Mitelman database showed approximately 100 cases of T cell acute lymphoblastic leukemia with t(11;14)(p13;q11). The most common additional cytogenetic aberrations were deletion 6q and deletion 9p in approximately 12% of cases and then trisomy 8 and trisomy 17 in about 3% of cases. Although prognostic significance of this translocation has not been clearly determined yet, it was accompanied by an early relapse after hematopoietic stem cell transplantation in this patient.