Blood Res 2021; 56(3):
Published online September 30, 2021
https://doi.org/10.5045/br.2021.2021098
© The Korean Society of Hematology
Correspondence to : Jean-Baptiste Rieu, Ph.D., Haematology Laboratory, Institut Universitaire du Cancer-Oncopole, 1 Avenue Irène Joliot-Curie 31100 Toulouse, France, E-mail: rieu.jeanbaptiste@iuct-oncopole.fr
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
A 79-year-old male was referred for non-regenerative anaemia (haemoglobin, 93 g/L). His blood examination revealed normal platelet (373×109/L) and WBC (6.4×109/L) count and differentials (neutrophils, 64%; lymphocytes, 21%; monocytes, 15%). Bone marrow examination did not reveal dysplastic changes or excess blasts (A and B, May-Grünwald-Giemsa, ×630). Lymphocytes represented 9% of total cells with normal morphology. The proportion of plasma cells was not increased (2%) but some possessed intranuclear pseudo-inclusions, known as Dutcher bodies (C, ×1,000), without any morphological changes commonly related to malignancy (such as nuclear-cytoplasmic asynchrony). Some mast cells were present (D, ×1,000). Despite the absence of atypical lymphoid involvement, these findings suggested the presence of mature B cell neoplasm, especially lymphoplasmacytic lymphoma (LPL). Flow cytometric immunophenotyping revealed lambda monotypic B cells population (E) representing 1% of leukocytes with co-expression of CD19, CD20, and CD79a, without CD5, CD23, and CD10. Molecular genetic analysis revealed
Blood Res 2021; 56(3): 125-125
Published online September 30, 2021 https://doi.org/10.5045/br.2021.2021098
Copyright © The Korean Society of Hematology.
Ali El Kassir1, Laetitia Largeaud1, Inès Vergnolle1, Lucie Oberic2, Anais Schavgoulidze1, Jean-Baptiste Rieu1
1Haematology Laboratory, 2Department of Clinical Haematology, Cancer University Institute of Toulouse – Oncopole, Toulouse, France
Correspondence to:Jean-Baptiste Rieu, Ph.D., Haematology Laboratory, Institut Universitaire du Cancer-Oncopole, 1 Avenue Irène Joliot-Curie 31100 Toulouse, France, E-mail: rieu.jeanbaptiste@iuct-oncopole.fr
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
A 79-year-old male was referred for non-regenerative anaemia (haemoglobin, 93 g/L). His blood examination revealed normal platelet (373×109/L) and WBC (6.4×109/L) count and differentials (neutrophils, 64%; lymphocytes, 21%; monocytes, 15%). Bone marrow examination did not reveal dysplastic changes or excess blasts (A and B, May-Grünwald-Giemsa, ×630). Lymphocytes represented 9% of total cells with normal morphology. The proportion of plasma cells was not increased (2%) but some possessed intranuclear pseudo-inclusions, known as Dutcher bodies (C, ×1,000), without any morphological changes commonly related to malignancy (such as nuclear-cytoplasmic asynchrony). Some mast cells were present (D, ×1,000). Despite the absence of atypical lymphoid involvement, these findings suggested the presence of mature B cell neoplasm, especially lymphoplasmacytic lymphoma (LPL). Flow cytometric immunophenotyping revealed lambda monotypic B cells population (E) representing 1% of leukocytes with co-expression of CD19, CD20, and CD79a, without CD5, CD23, and CD10. Molecular genetic analysis revealed