Blood Res 2020; 55(4):
Published online December 31, 2020
https://doi.org/10.5045/br.2020.2020156
© The Korean Society of Hematology
Correspondence to : Pasquale Niscola, M.D., Hematology Unit, St. Eugenio Hospital, ASL Roma 2, Piazzale dell’Umanesimo 10, Rome 00144, Italy E-mail: pniscola@gmail.com
This is an Open Access article distributed unAcute myeloid leukemia, New FDA approvalsder the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Systemic oxalosis is a rare autosomal recessive genetic metabolic disorder with an estimated prevalence of less than 1 case/million individuals/year. Alanine glyoxylate aminotransferase deficiency, leading to the endogenous overproduction of oxalic acid as well as the multisystem deposition of calcium oxalate crystals, including kidneys, cartilage, bone, soft tissues, liver, spleen, retina, peripheral nerves, and heart, whereas their bone marrow (BM) localization is very rarely observed. Chronic renal failure (CRF) and pancytopenia being the main clinical consequences. Herein, we describe the case of a 29-year-old woman with CRF on regular hemodialysis and transfusions. Her past medical history revealed primary hyperoxaluria. Blood count showed pancytopenia. Urinalysis revealed hyperoxaluria at 0.84 mmol/L. BM histopathology revealed extensive deposition of large oxalate needle-like crystals arranged in a radial pattern within bony trabeculae
Blood Res 2020; 55(4): 192-192
Published online December 31, 2020 https://doi.org/10.5045/br.2020.2020156
Copyright © The Korean Society of Hematology.
Stefano Fratoni1, Pasquale Niscola2
1Surgical Pathology, Hematopathology Unit, 2Haematology Unit, St. Eugenio Hospital, Rome, Italy
Correspondence to:Pasquale Niscola, M.D., Hematology Unit, St. Eugenio Hospital, ASL Roma 2, Piazzale dell’Umanesimo 10, Rome 00144, Italy E-mail: pniscola@gmail.com
This is an Open Access article distributed unAcute myeloid leukemia, New FDA approvalsder the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Systemic oxalosis is a rare autosomal recessive genetic metabolic disorder with an estimated prevalence of less than 1 case/million individuals/year. Alanine glyoxylate aminotransferase deficiency, leading to the endogenous overproduction of oxalic acid as well as the multisystem deposition of calcium oxalate crystals, including kidneys, cartilage, bone, soft tissues, liver, spleen, retina, peripheral nerves, and heart, whereas their bone marrow (BM) localization is very rarely observed. Chronic renal failure (CRF) and pancytopenia being the main clinical consequences. Herein, we describe the case of a 29-year-old woman with CRF on regular hemodialysis and transfusions. Her past medical history revealed primary hyperoxaluria. Blood count showed pancytopenia. Urinalysis revealed hyperoxaluria at 0.84 mmol/L. BM histopathology revealed extensive deposition of large oxalate needle-like crystals arranged in a radial pattern within bony trabeculae