Blood Res  
Thromboprophylaxis after bariatric surgery
Feras M. Almarshad1, Mosaad Almegren2, Turki Alshuaibi3, Nadiah Alobaodi3, Ali Almutawa3, Hajer Basunbl3, Farjah AlGahtani4, Bader Al Rawahi5
College of Medicine, 1Shaqra University, Shaqra, 2Al Imam Mohammad Ibn Saud Islamic University, Riyadh, Department of Medicine, 3King Fahd Hospital, Jeddah, 4King Saud University, Riyadh, Saudi Arabia, 5Sultan Qaboos University, Sultan Qaboos University Hospital, Oman
Correspondence to: Feras M. Almarshad, M.D.
College of Medicine, Shaqra University, Shaqraa, Riyadh, Saudi Arabia
E-mail: feras-mmm@hotmail.com
Published online: March 13, 2020.
© The Korean Journal of Hematology. All rights reserved.

Abstract
Background: Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE), is a known cause of morbidity and mortality after bariatric surgery. However, the data concerning appropriate thromboprophylaxis after bariatric surgery is uncertain. The objective of this study was to evaluate the efficacy and safety of extended duration thromboprophylaxis in post-bariatric surgery patients.
Methods: We conducted a retrospective study of consecutive patients who underwent bariatric surgery from November 2014 to October 2018 at King Fahad General Hospital in Jeddah, Saudi Arabia. All included patients were treated with extended duration thromboprophylaxis.
Results: We identified 374 patients who underwent bariatric surgery during the study period. Of these, 312 patients (83%) were followed for at least 3 months. The most common type of surgery was a laparoscopic sleeve gastrectomy (N=357) and the median weight was 110 kg. The cumulative incidence of symptomatic postoperative VTE at 3 months was 0.64% (95% confidence interval, 0.20–1.52). All events occurred after hospital discharge. The most commonly used pharmacological prophylaxis (91%) for VTE prevention after bariatric surgery was enoxaparin 40 mg subcutaneously twice daily for 10–14 days after hospital discharge. There were no reported cases of bleeding or VTE related mortality after 3 months.
Conclusion: Extended thromboprophylaxis after bariatric surgery appears to be an effective and safe strategy for VTE prevention. Large prospective studies are needed to evaluate the optimal thromboprophylaxis regimen after bariatric surgery.
Keywords: Bariatric surgery, Venous thromboembolism, Deep vein thrombosis, Pulmonary embolism, Thromboprophylaxis


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