Comparison of quality of life and depression between hematopoietic stem cell transplantation survivors and their spouse caregivers

Silvia Park; Eun-kyung Choi; Im-Ryung Kim; Juhee Cho; Jun Ho Jang

doi:10.5045/br.2019.54.2.137

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Original Article

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Blood Res 2019; 54(2):

Published online June 30, 2019

https://doi.org/10.5045/br.2019.54.2.137

Comparison of quality of life and depression between hematopoietic stem cell transplantation survivors and their spouse caregivers

Silvia Park^1,2, Eun-kyung Choi⁴, Im-Ryung Kim⁴, Juhee Cho^4,5,6, Jun Ho Jang³

Author Info. +

¹Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary’s Hospital, ²Leukemia Research Institute, College of Medicine, The Catholic University of Korea, ³Division of Hematology-Oncology, Department of Medicine, ⁴Cancer Education Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, ⁵Department of Clinical Research Design and Evaluation, SAIHST, Sungkyunkwan University, Seoul, Korea, ⁶Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

Correspondence to : Jun Ho Jang, M.D., Ph.D., Juhee Cho, Ph.D.
Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea (J.H.J.)
Department of Clinical Research Design and Evaluation, SAIHST, Sungkyunkwan University, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea (J.C.)
E-mail: J.H.J., jh21.jang@samsung.com, J.C., jcho@skku.edu

Received: October 30, 2018; Revised: March 30, 2019; Accepted: April 1, 2019

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

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Abstract

Background

Hematopoietic stem cell transplantation (HSCT) is an exhausting process that impacts both the patient and caregiver.

Methods

This was a cross-sectional, HSCT survivor-spouse caregiver matching study to determine quality of life (QoL) and depression among HSCT survivors and their caregivers. QoL and depression were measured with the World Health Organization Quality of Life: Brief Version (26 items) and the 9-item Patient Health Questionnaire, respectively. Data from 97 married couples were analyzed.

Results

There were no significant differences in overall QoL and psychological, social, and environmental health between survivors and spouse caregivers (P=0.345, 0.424, 0.415, and 0.253); however, physical QoL was better in the spouse caregiver group (P=0.011). There was no difference in mean depression scale scores (5.3 vs. 5.1, P=0.812) or proportion of severe depression (15.6% vs. 13.7%, P=0.270) between the two groups. We found that family income had a significant impact on overall QoL and environmental health among spouse caregivers (P=0.013 and 0.023), and female gender, co-morbidities, and family income were the important factors associated with depression among spouse caregivers (P=0.007, 0.017 and 0.049).

Conclusion

This study found that there were no significant differences in QoL or level of depression between HSCT survivors and their spouse caregivers. Family income, gender, and co-morbidities showed significant association with spouse caregiver distress.

Keywords Hematopoietic stem cell transplantation, Survivor, Caregiver, Quality of life, Depression

Article

Original Article

Blood Res 2019; 54(2): 137-143

Published online June 30, 2019 https://doi.org/10.5045/br.2019.54.2.137

Comparison of quality of life and depression between hematopoietic stem cell transplantation survivors and their spouse caregivers

Silvia Park^1,2, Eun-kyung Choi⁴, Im-Ryung Kim⁴, Juhee Cho^4,5,6, Jun Ho Jang³

Correspondence to:Jun Ho Jang, M.D., Ph.D., Juhee Cho, Ph.D.
Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea (J.H.J.)
Department of Clinical Research Design and Evaluation, SAIHST, Sungkyunkwan University, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea (J.C.)
E-mail: J.H.J., jh21.jang@samsung.com, J.C., jcho@skku.edu

Received: October 30, 2018; Revised: March 30, 2019; Accepted: April 1, 2019

Abstract

Background

Hematopoietic stem cell transplantation (HSCT) is an exhausting process that impacts both the patient and caregiver.

Methods

Results

Conclusion

Keywords: Hematopoietic stem cell transplantation, Survivor, Caregiver, Quality of life, Depression

Abstract

Fig 1.

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Figure 1.

Flow diagram of subject enrollment.

Blood Research 2019; 54: 137-143https://doi.org/10.5045/br.2019.54.2.137

Table 1 Characteristics of participants.

Abbreviations: GVHD, chronic graft versus host disease; HSCT, hematopoietic stem cell transplantation..

Table 2 Comparison of quality of life and depression between HSCT survivors and their spouse caregivers.

^a)1=“strongly disagree”, 2=“disagree”, 3=“neither”, 4=“agree”, 5=“strongly agree”, Thus, a higher mean indicates better quality of life. ^b)1=“not at all”, 2=“a little”, 3=“quite a bit”, 4=“very much”, Thus, a higher mean indicates more severe depression..

Abbreviations: HSCT, hematopoietic stem cell transplantation; SD, standard deviation..

Table 3 Factors associated with quality of life and depression among spouse caregivers.<sup>a,b)</sup>

^a)For coefficients, a negative value indicates a negative relationship between the variables. ^b)P<0.05. ^c)P=0.013. ^d)P=0.023. ^e)P=0.032. ^f)P=0.049. ^g)P=0.007. ^h)P=0.017..

Abbreviations: coef., coefficient; GVHD, chronic graft versus host disease; HSCT, hematopoietic stem cell transplantation; ref., reference; SE, standard error; WHOQOL-BREF 26, World Health Organization Quality of Life: Brief Version (26 items)..