Original Article
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Blood Res 2019; 54(1):
Published online March 31, 2019
https://doi.org/10.5045/br.2019.54.1.52
© The Korean Society of Hematology
Analysis of hematologic parameters of donors, patients, and granulocyte concentrates to predict successful granulocyte transfusion
1Department of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
2Department of Hematology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Correspondence to : Correspondence to Jihyang Lim, M.D., Ph.D. Department of Laboratory Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, 222 Banpodaero, Seocho-gu, Seoul 06591, Korea. ljh117@catholic.ac.kr
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background
Granulocyte transfusion (GTx) is performed as a supportive therapy in severe neutropenic patients caused by various conditions. The study aimed to analyze the hematologic parameters of donors, patients, and granulocyte concentrates to predict successful GTx.
Methods
This study was performed in 281 donors, with their granulocyte concentrates being collected through apheresis, and in 54 severe neutropenic patients who had various hematologic diseases. Complete blood cell counts of donors pre- and post-apheresis, granulocyte concentrates, and patients pre- and post-GTx were analyzed. Patients were divided into two groups according to survival at discharge (Group S, survival; Group D, dead) to compare various factors including age, infection status, pre- and post-GTx total white blood cell counts (TWBCC) and absolute neutrophil counts (ANC), total number of GTx, infused TWBCC and ANC per weight, and use of G-CSF during therapy.
Results
Overall data of patients showed that both TWBCC and ANC were significantly increased after GTx (median values at pre-GTx, TWBCC=0.40×109/L, ANC=0.14×109/L; post-GTx, TWBCC=0.57×109/L, ANC=0.29×109/L, both
Conclusion
The TWBCC and ANC after GTx were significant factors to predict patients' outcome. Therefore, follow-up of those two parameters may be helpful to select or consider other therapeutic modalities including additional GTx.
Keywords Granulocyte transfusion, Neutropenia, Total white blood cell counts, Absolute neutrophil counts, Granulocyte colony-stimulating factor
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Original Article
Blood Res 2019; 54(1): 52-56
Published online March 31, 2019 https://doi.org/10.5045/br.2019.54.1.52
Copyright © The Korean Society of Hematology.
Analysis of hematologic parameters of donors, patients, and granulocyte concentrates to predict successful granulocyte transfusion
Jong-Mi Lee1, Seung Jun Choi1, Hoon Seok Kim1, Mina Yang1, Yonggoo Kim1, Jong Wook Lee2, and Jihyang Lim1*
1Department of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
2Department of Hematology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Correspondence to: Correspondence to Jihyang Lim, M.D., Ph.D. Department of Laboratory Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, 222 Banpodaero, Seocho-gu, Seoul 06591, Korea. ljh117@catholic.ac.kr
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background
Granulocyte transfusion (GTx) is performed as a supportive therapy in severe neutropenic patients caused by various conditions. The study aimed to analyze the hematologic parameters of donors, patients, and granulocyte concentrates to predict successful GTx.
Methods
This study was performed in 281 donors, with their granulocyte concentrates being collected through apheresis, and in 54 severe neutropenic patients who had various hematologic diseases. Complete blood cell counts of donors pre- and post-apheresis, granulocyte concentrates, and patients pre- and post-GTx were analyzed. Patients were divided into two groups according to survival at discharge (Group S, survival; Group D, dead) to compare various factors including age, infection status, pre- and post-GTx total white blood cell counts (TWBCC) and absolute neutrophil counts (ANC), total number of GTx, infused TWBCC and ANC per weight, and use of G-CSF during therapy.
Results
Overall data of patients showed that both TWBCC and ANC were significantly increased after GTx (median values at pre-GTx, TWBCC=0.40×109/L, ANC=0.14×109/L; post-GTx, TWBCC=0.57×109/L, ANC=0.29×109/L, both
Conclusion
The TWBCC and ANC after GTx were significant factors to predict patients' outcome. Therefore, follow-up of those two parameters may be helpful to select or consider other therapeutic modalities including additional GTx.
Keywords: Granulocyte transfusion, Neutropenia, Total white blood cell counts, Absolute neutrophil counts, Granulocyte colony-stimulating factor
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Comparison of total white blood cell count and absolute neutrophil count of donors and their granulocyte concentrates. a)Total collection volume of granulocyte concentrates was 350 mL. b)TWBCC of donors' blood before and after G-CSF administration. c)TWBCC and ANC of donors after G-CSF administration and their GC..
Abbreviations: ANC, absolute neutrophil count; GC, granulocyte concentrates; G-CSF, granulocyte colony-stimulating factor; TWBCC, total white blood cell count..
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Median of patients' TWBCC and ANC changes according to granulocyte transfusion. a)
P -values were determined using Mann-Whitney test..Abbreviations: ANC, absolute neutrophil count; TWBCC, total white blood cell count..
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Baseline characteristics of the subjects. a)
P -values were determined using Mann-Whitney test for continuous variables and Fisher's exact test for categorical variables..Abbreviations: Group D, dead patients at discharge; Group S, survived patients at discharge..
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Variables associated with response to granulocyte transfusion. Abbreviations: ANC, absolute neutrophil count; Group D, dead patients at discharge; Group S, survived patients at discharge; GTx, granulocyte transfusion; TWBCC, total white blood cell count..
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