SitemapContact Us
닫기
Search
Advanced Search +
닫기
Quick links
Most Cited Most Read Ahead of Print Archives Go to E-submission

Letter to the Editor

Split Viewer

Blood Res 2018; 53(3):

Published online September 28, 2018

https://doi.org/10.5045/br.2018.53.3.261

© The Korean Society of Hematology

Low-grade follicular lymphoma involvement of the bone marrow with a mixed paratrabecular, diffuse, and massive pattern expressing typical mantle cell lymphoma immunophenotype CD23−/FMC7+: a case report

Jaewook Kim1, Ji-Hun Lim1, Joseph Jeong1, Seon-Ho Lee1, Jae-Cheol Jo2, and Sang Hyuk Park1*

Author Info. +

1Department of Laboratory Medicine, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Korea.

2Department of Hematology and Cellular Therapy, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Korea.

Correspondence to : Sang Hyuk Park. Department of Laboratory Medicine, University of Ulsan College of Medicine, Ulsan University Hospital, Bangujin-sunhwandoro 877, Dong-gu, Ulsan 44033, Korea. korailman-1@hanmail.net

Received: July 12, 2018; Revised: August 2, 2018; Accepted: August 5, 2018

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

FIGURES

Go to
Fig. 1.

Peripheral blood smears, bone marrow aspiration and touch print, bone marrow biopsy, and immunohistochemical staining results of our case. (A) Neoplastic lymphoid cells found in peripheral blood smear showed small-to-medium, cleaved nuclei and scant amount of cytoplasm (indicated by red arrows, Wright-Giemsa stain, ×400). (B) Neoplastic lymphoid cells found in the bone marrow aspirates also showed a small-to-medium, cleavage nucleus, and scant amount of cytoplasm as morphologic features (indicated by red arrows, Wright-Giemsa stain, ×400). (C) Neoplastic lymphoid cells found in touch print of the bone marrow also showed similar morphologic features (indicated by red arrows, Wright-Giemsa stain, ×400). (D) Bone marrow biopsy section showed infiltration of neoplastic lymphoid cells with a mixture of paratrabecular (indicated by red circle) and intertrabecular (indicated by blue circles) infiltration pattern (hematoxylin and eosin stain, × 100). (E, F) Neoplastic lymphoid cell did not show positivity on CD3 and CD5 immunohistochemical staining (×100). (G) However, neoplastic lymphoid cells showed strong membranous positivity for CD20 immunohistochemical staining (×100). (H, I) Neoplastic lymphoid cells found in paratrabecular areas showed strong nuclear positivity for BCL6, but those found in intertrabecular areas showed weak nuclear positivity for BCL6 (×100 and ×200, respectively).


REFERENCES

Go to
  1. Freedman A. Follicular lymphoma: 2014 update on diagnosis and management. Am J Hematol 2014;89:429-436.
    Pubmed
  2. Kim JM, Ko YH, Lee SS, et al. WHO classification of malignant lymphomas in Korea: report of the third nationwide study. Korean J Pathol 2011;45:254-260.
  3. Swerdlow SH, Campo E, Harris NL. WHO classification of tumours of haematopoietic and lymphoid tissues. Revised 4th ed. Lyon, France: IARC Press; 2017. p. 266-290.
  4. Arber DA, George TI. Bone marrow biopsy involvement by non-Hodgkin's lymphoma: frequency of lymphoma types, patterns, blood involvement, and discordance with other sites in 450 specimens. Am J Surg Pathol 2005;29:1549-1557.
    Pubmed
  5. Garcia DP, Rooney MT, Ahmad E, Davis BH. Diagnostic usefulness of CD23 and FMC-7 antigen expression patterns in B-cell lymphoma classification. Am J Clin Pathol 2001;115:258-265.
    Pubmed
  6. Liu Y, Li P, Guo Y, et al. A unique composite follicular lymphoma and mantle cell lymphoma with a mixed cell pattern and aggressive course. Am J Clin Pathol 2014;141:737-741.
    Pubmed
  7. Iancu D, Hao S, Lin P, et al. Follicular lymphoma in staging bone marrow specimens: correlation of histologic findings with the results of flow cytometry immunophenotypic analysis. Arch Pathol Lab Med 2007;131:282-287.
    Pubmed
  8. Trimaldi JA, Bowers JW, Bello C, Sagatys EM. Follicular lymphoma with progression to diffuse large B-cell lymphoma and concurrent CD5-negative mantle cell lymphoma-3 entities in a lymph node. Cancer Control 2014;21:251-254.
    Pubmed

Article

Letter to the Editor

Blood Res 2018; 53(3): 261-263

Published online September 28, 2018 https://doi.org/10.5045/br.2018.53.3.261

Copyright © The Korean Society of Hematology.

Low-grade follicular lymphoma involvement of the bone marrow with a mixed paratrabecular, diffuse, and massive pattern expressing typical mantle cell lymphoma immunophenotype CD23−/FMC7+: a case report

Jaewook Kim1, Ji-Hun Lim1, Joseph Jeong1, Seon-Ho Lee1, Jae-Cheol Jo2, and Sang Hyuk Park1*

1Department of Laboratory Medicine, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Korea.

2Department of Hematology and Cellular Therapy, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Korea.

Correspondence to: Sang Hyuk Park. Department of Laboratory Medicine, University of Ulsan College of Medicine, Ulsan University Hospital, Bangujin-sunhwandoro 877, Dong-gu, Ulsan 44033, Korea. korailman-1@hanmail.net

Received: July 12, 2018; Revised: August 2, 2018; Accepted: August 5, 2018

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

    Fig 1.

    Download
    Figure 1.

    Peripheral blood smears, bone marrow aspiration and touch print, bone marrow biopsy, and immunohistochemical staining results of our case. (A) Neoplastic lymphoid cells found in peripheral blood smear showed small-to-medium, cleaved nuclei and scant amount of cytoplasm (indicated by red arrows, Wright-Giemsa stain, ×400). (B) Neoplastic lymphoid cells found in the bone marrow aspirates also showed a small-to-medium, cleavage nucleus, and scant amount of cytoplasm as morphologic features (indicated by red arrows, Wright-Giemsa stain, ×400). (C) Neoplastic lymphoid cells found in touch print of the bone marrow also showed similar morphologic features (indicated by red arrows, Wright-Giemsa stain, ×400). (D) Bone marrow biopsy section showed infiltration of neoplastic lymphoid cells with a mixture of paratrabecular (indicated by red circle) and intertrabecular (indicated by blue circles) infiltration pattern (hematoxylin and eosin stain, × 100). (E, F) Neoplastic lymphoid cell did not show positivity on CD3 and CD5 immunohistochemical staining (×100). (G) However, neoplastic lymphoid cells showed strong membranous positivity for CD20 immunohistochemical staining (×100). (H, I) Neoplastic lymphoid cells found in paratrabecular areas showed strong nuclear positivity for BCL6, but those found in intertrabecular areas showed weak nuclear positivity for BCL6 (×100 and ×200, respectively).

    Blood Research 2018; 53: 261-263https://doi.org/10.5045/br.2018.53.3.261

    References

    1. Freedman A. Follicular lymphoma: 2014 update on diagnosis and management. Am J Hematol 2014;89:429-436.
      Pubmed
    2. Kim JM, Ko YH, Lee SS, et al. WHO classification of malignant lymphomas in Korea: report of the third nationwide study. Korean J Pathol 2011;45:254-260.
    3. Swerdlow SH, Campo E, Harris NL. WHO classification of tumours of haematopoietic and lymphoid tissues. Revised 4th ed. Lyon, France: IARC Press; 2017. p. 266-290.
    4. Arber DA, George TI. Bone marrow biopsy involvement by non-Hodgkin's lymphoma: frequency of lymphoma types, patterns, blood involvement, and discordance with other sites in 450 specimens. Am J Surg Pathol 2005;29:1549-1557.
      Pubmed
    5. Garcia DP, Rooney MT, Ahmad E, Davis BH. Diagnostic usefulness of CD23 and FMC-7 antigen expression patterns in B-cell lymphoma classification. Am J Clin Pathol 2001;115:258-265.
      Pubmed
    6. Liu Y, Li P, Guo Y, et al. A unique composite follicular lymphoma and mantle cell lymphoma with a mixed cell pattern and aggressive course. Am J Clin Pathol 2014;141:737-741.
      Pubmed
    7. Iancu D, Hao S, Lin P, et al. Follicular lymphoma in staging bone marrow specimens: correlation of histologic findings with the results of flow cytometry immunophenotypic analysis. Arch Pathol Lab Med 2007;131:282-287.
      Pubmed
    8. Trimaldi JA, Bowers JW, Bello C, Sagatys EM. Follicular lymphoma with progression to diffuse large B-cell lymphoma and concurrent CD5-negative mantle cell lymphoma-3 entities in a lymph node. Cancer Control 2014;21:251-254.
      Pubmed
    Blood Res
    Volume 59 2024
    Current Issue Archives

    Stats or Metrics

    Share this article on

    • line

    Blood Research

    pISSN 2287-979X
    eISSN 2288-0011
    qr-code Download