Letter to the Editor

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Blood Res 2018; 53(3):

Published online September 28, 2018

https://doi.org/10.5045/br.2018.53.3.254

© The Korean Society of Hematology

Emergence of chronic myeloid leukemia following autologous stem cell transplantation in a young woman with multiple myeloma

Aisling Barrett*, Siobhán Glavey, Jeremy Sargent, Patrick Thornton, Philip Murphy, and John Quinn

Department of Hematology, Beaumont Hospital, Dublin, Ireland.

Correspondence to : Aisling Barrett. Department of Hematology, Beaumont Hospital, P.O. Box 1297, Beaumont Road, Dublin 9, Ireland. aibarret@tcd.ie

Received: March 13, 2018; Revised: April 17, 2018; Accepted: May 10, 2018

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Fig. 1.

Bone marrow at the time of multiple myeloma (MM) diagnosis. A hypercellular particle with atypical plasma cells under low power (A). Numerous atypical plasma cells under high power (B).


Fig. 2.

Bone marrow at the time of chronic myeloid leukemia (CML) diagnosis. A hypercellular particle under low power (A). A high-power view of granulocytic hyperplasia (B).


Table. 1.

Table 1 Reported cases of CML following MM diagnosis.

Abbreviations: CML, chronic myeloid leukemia; MM, multiple myeloma.


  1. Lee JY, Lee SM, Yoon HK, Kim KH, Choi MY, Lee WS. A case of synchronous multiple myeloma and chronic myeloid leukemia. Blood Res 2017;52:219-222.
    Pubmed
  2. Thomas A, Mailankody S, Korde N, Kristinsson SY, Turesson I, Landgren O. Second malignancies after multiple myeloma: from 1960s to 2010s. Blood 2012;119:2731-2737.
    Pubmed
  3. Wolleschak D, Heidel FH. Chronic myelogenous leukemia evolving after treatment of multiple myeloma. Blood 2016;128:146.
    Pubmed
  4. Alsidawi S, Ghose A, Qualtieri J, Radhakrishnan N. A case of multiple myeloma with metachronous chronic myeloid leukemia treated successfully with bortezomib, dexamethasone, and dasatinib. Case Rep Oncol Med 2014;2014:962526.
    Pubmed
  5. Pessach I, Bartzis V, Tzenou T, et al. Multiple myeloma and chronic myelogenous leukemia; an uncommon coexistence in 2 patients, with literature review. Ann Hematol Oncol 2015;2:1030.
  6. Nakagawa M, Noto S, Kobayashi H, Hayashi M. A case of a 47 year old man who developed chronic myelogenous leukemia after therapy for multiple myeloma. J Obihiro Kosei Gen Hosp 2003;6:101-106.
  7. Nitta M, Tsuboi K, Yamashita S, et al. Multiple myeloma preceding the development of chronic myelogenous leukemia. Int J Hematol 1999;69:170-173.
    Pubmed
  8. Klenn PJ, Hyun BH, Lee YH, Zheng WY. Multiple myeloma and chronic myelogenous leukemia-a case report with literature review. Yonsei Med J 1993;34:293-300.
    Pubmed
  9. MacSween JM, Langley GR. Light-chain disease (hypogammaglobulinemia and Bence Jones proteinuria) and sideroblastic anemia-preleukemic chronic granulocytic leukemia. Can Med Assoc J 1972;106:995-998.
    Pubmed
  10. Ragupathi L, Najfeld V, Chari A, Petersen B, Jagannath S, Mascarenhas J. A case report of chronic myelogenous leukemia in a patient with multiple myeloma and a review of the literature. Clin Lymphoma Myeloma Leuk 2013;13:175-179.
    Pubmed

Article

Letter to the Editor

Blood Res 2018; 53(3): 254-256

Published online September 28, 2018 https://doi.org/10.5045/br.2018.53.3.254

Copyright © The Korean Society of Hematology.

Emergence of chronic myeloid leukemia following autologous stem cell transplantation in a young woman with multiple myeloma

Aisling Barrett*, Siobhán Glavey, Jeremy Sargent, Patrick Thornton, Philip Murphy, and John Quinn

Department of Hematology, Beaumont Hospital, Dublin, Ireland.

Correspondence to: Aisling Barrett. Department of Hematology, Beaumont Hospital, P.O. Box 1297, Beaumont Road, Dublin 9, Ireland. aibarret@tcd.ie

Received: March 13, 2018; Revised: April 17, 2018; Accepted: May 10, 2018

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

    Fig 1.

    Figure 1.

    Bone marrow at the time of multiple myeloma (MM) diagnosis. A hypercellular particle with atypical plasma cells under low power (A). Numerous atypical plasma cells under high power (B).

    Blood Research 2018; 53: 254-256https://doi.org/10.5045/br.2018.53.3.254

    Fig 2.

    Figure 2.

    Bone marrow at the time of chronic myeloid leukemia (CML) diagnosis. A hypercellular particle under low power (A). A high-power view of granulocytic hyperplasia (B).

    Blood Research 2018; 53: 254-256https://doi.org/10.5045/br.2018.53.3.254

    Table 1 . Reported cases of CML following MM diagnosis..

    Abbreviations: CML, chronic myeloid leukemia; MM, multiple myeloma..


    References

    1. Lee JY, Lee SM, Yoon HK, Kim KH, Choi MY, Lee WS. A case of synchronous multiple myeloma and chronic myeloid leukemia. Blood Res 2017;52:219-222.
      Pubmed
    2. Thomas A, Mailankody S, Korde N, Kristinsson SY, Turesson I, Landgren O. Second malignancies after multiple myeloma: from 1960s to 2010s. Blood 2012;119:2731-2737.
      Pubmed
    3. Wolleschak D, Heidel FH. Chronic myelogenous leukemia evolving after treatment of multiple myeloma. Blood 2016;128:146.
      Pubmed
    4. Alsidawi S, Ghose A, Qualtieri J, Radhakrishnan N. A case of multiple myeloma with metachronous chronic myeloid leukemia treated successfully with bortezomib, dexamethasone, and dasatinib. Case Rep Oncol Med 2014;2014:962526.
      Pubmed
    5. Pessach I, Bartzis V, Tzenou T, et al. Multiple myeloma and chronic myelogenous leukemia; an uncommon coexistence in 2 patients, with literature review. Ann Hematol Oncol 2015;2:1030.
    6. Nakagawa M, Noto S, Kobayashi H, Hayashi M. A case of a 47 year old man who developed chronic myelogenous leukemia after therapy for multiple myeloma. J Obihiro Kosei Gen Hosp 2003;6:101-106.
    7. Nitta M, Tsuboi K, Yamashita S, et al. Multiple myeloma preceding the development of chronic myelogenous leukemia. Int J Hematol 1999;69:170-173.
      Pubmed
    8. Klenn PJ, Hyun BH, Lee YH, Zheng WY. Multiple myeloma and chronic myelogenous leukemia-a case report with literature review. Yonsei Med J 1993;34:293-300.
      Pubmed
    9. MacSween JM, Langley GR. Light-chain disease (hypogammaglobulinemia and Bence Jones proteinuria) and sideroblastic anemia-preleukemic chronic granulocytic leukemia. Can Med Assoc J 1972;106:995-998.
      Pubmed
    10. Ragupathi L, Najfeld V, Chari A, Petersen B, Jagannath S, Mascarenhas J. A case report of chronic myelogenous leukemia in a patient with multiple myeloma and a review of the literature. Clin Lymphoma Myeloma Leuk 2013;13:175-179.
      Pubmed
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