Letter to the Editor

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Blood Res 2018; 53(3):

Published online September 28, 2018

https://doi.org/10.5045/br.2018.53.3.250

© The Korean Society of Hematology

A misleading presentation of T cell/histiocyte rich B-cell lymphoma mimicking osteomyelitis

Tahsin Özpolat1*, Bulent Saka2, Ipek Yonal-Hindilerden3, Cemil Tascioglu2, Öner Dogan4, and Meliha Nalcaci3

1Bloodworks Research Institute, Seattle, WA, USA.

2Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.

3Department of Hematology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.

4Department of Pathology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.

Correspondence to : Tahsin Özpolat. Bloodworks Research Institute, 1551 Eastlake Ave E Suite 100, Seattle, WA 98102, USA. tahsino@bloodworksnw.org

Received: January 27, 2018; Revised: February 28, 2018; Accepted: May 10, 2018

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Fig. 1.

A triphasic bone scan scintigraphy showed increased late-phase activity in the frontal and parietal bones, right hip joint, right femoral condyle, right proximal, distal epiphyses of the tibia, and right tarsal bones.


Fig. 2.

Bone marrow biopsy showed infiltration of T-cell/histiocyte-rich B-cell lymphoma (TC/HRBCL). (A) Scattered large atypical cells in a lymphohistiocytic background (H&E, ×1,000). (B) Scattered atypical B cells labeled with CD20 antibody, CD20 (×200). (C) Infiltration of reactive T cells with a nodular pattern labeled with CD3 antibody, CD3 (×200).


  1. Unni KK, Hogendoorn PCW. In: Fletcher CDM, Unni KK, Mertens F. Malignant lymphoma. Lyon, France: IARC Press; 2002. p. 306-308.
  2. Choi JY, Hahn JS, Suh CO, Yang WI. Primary lymphoma of bone-survival and prognosis. Korean J Intern Med 2002;17:191-197.
    Pubmed
  3. Cabanela ME, Sim FH, Beabout JW, Dahlin DC. Osteomyelitis appearing as neoplasms. A diagnostic problem. Arch Surg 1974;109:68-72.
    Pubmed
  4. El Weshi A, Akhtar S, Mourad WA, et al. T-cell/histiocyte-rich B-cell lymphoma: clinical presentation, management and prognostic factors: report on 61 patients and review of literature. Leuk Lymphoma 2007;48:1764-1773.
    Pubmed

Article

Letter to the Editor

Blood Res 2018; 53(3): 250-251

Published online September 28, 2018 https://doi.org/10.5045/br.2018.53.3.250

Copyright © The Korean Society of Hematology.

A misleading presentation of T cell/histiocyte rich B-cell lymphoma mimicking osteomyelitis

Tahsin Özpolat1*, Bulent Saka2, Ipek Yonal-Hindilerden3, Cemil Tascioglu2, Öner Dogan4, and Meliha Nalcaci3

1Bloodworks Research Institute, Seattle, WA, USA.

2Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.

3Department of Hematology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.

4Department of Pathology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.

Correspondence to: Tahsin Özpolat. Bloodworks Research Institute, 1551 Eastlake Ave E Suite 100, Seattle, WA 98102, USA. tahsino@bloodworksnw.org

Received: January 27, 2018; Revised: February 28, 2018; Accepted: May 10, 2018

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

    Fig 1.

    Figure 1.

    A triphasic bone scan scintigraphy showed increased late-phase activity in the frontal and parietal bones, right hip joint, right femoral condyle, right proximal, distal epiphyses of the tibia, and right tarsal bones.

    Blood Research 2018; 53: 250-251https://doi.org/10.5045/br.2018.53.3.250

    Fig 2.

    Figure 2.

    Bone marrow biopsy showed infiltration of T-cell/histiocyte-rich B-cell lymphoma (TC/HRBCL). (A) Scattered large atypical cells in a lymphohistiocytic background (H&E, ×1,000). (B) Scattered atypical B cells labeled with CD20 antibody, CD20 (×200). (C) Infiltration of reactive T cells with a nodular pattern labeled with CD3 antibody, CD3 (×200).

    Blood Research 2018; 53: 250-251https://doi.org/10.5045/br.2018.53.3.250

    References

    1. Unni KK, Hogendoorn PCW. In: Fletcher CDM, Unni KK, Mertens F. Malignant lymphoma. Lyon, France: IARC Press; 2002. p. 306-308.
    2. Choi JY, Hahn JS, Suh CO, Yang WI. Primary lymphoma of bone-survival and prognosis. Korean J Intern Med 2002;17:191-197.
      Pubmed
    3. Cabanela ME, Sim FH, Beabout JW, Dahlin DC. Osteomyelitis appearing as neoplasms. A diagnostic problem. Arch Surg 1974;109:68-72.
      Pubmed
    4. El Weshi A, Akhtar S, Mourad WA, et al. T-cell/histiocyte-rich B-cell lymphoma: clinical presentation, management and prognostic factors: report on 61 patients and review of literature. Leuk Lymphoma 2007;48:1764-1773.
      Pubmed
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