Letter to the Editor

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Blood Res 2017; 52(4):

Published online December 31, 2017

https://doi.org/10.5045/br.2017.52.4.319

© The Korean Society of Hematology

Successful treatment of a patient with myelodysplastic syndrome accompanied by pyoderma gangrenosum and Behçet's disease using allogeneic stem cell transplantation

Seung-Shin Lee1, Jae-Sook Ahn1*, Sook Jung Yun2, and Dong-Jin Park3

1Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Korea.

2Department of Dermatology, Chonnam National University Hwasun Hospital, Hwasun, Korea.

3Division of Rheumatology, Chonnam National University Hwasun Hospital, Hwasun, Korea.

Correspondence to : Jae-Sook Ahn. Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, 322 Seoyangro, Hwasun-eup, Hwasun-gun, Jeonnam 58128, Korea. f0115@chonnam.ac.kr

Received: December 27, 2016; Revised: April 5, 2017; Accepted: May 25, 2017

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Fig. 1.

Presentation of clinical course after diagnosis of myelodysplastic syndrome (MDS). The facial granulomatous lesion at diagnosis (A), oral ulcer, suppurative ulcer on leg, and ulcerative lesion in ileum by colonoscopy (B). Improvement of the facial granulomatous lesion and leg ulcer after allogeneic stem cell transplantation (SCT) (C).


  1. Komrokji, RS, Zhang, L, Bennett, JM. Myelodysplastic syndromes classification and risk stratification. Hematol Oncol Clin North Am, 2010;24;443-457.
    Pubmed
  2. Al Ustwani, O, Ford, LA, Sait, SJ, et al. Myelodysplastic syndromes and autoimmune diseases-case series and review of literature. Leuk Res, 2013;37;894-899.
    Pubmed
  3. Komrokji, RS, Kulasekararaj, A, Al Ali, NH, et al. Autoimmune diseases and myelodysplastic syndromes. Am J Hematol, 2016;91;E280-E283.
    Pubmed
  4. Hagiwara, A, Fujimura, T, Furudate, S, et al. Generalized granulomatous dermatitis accompanied by myelodysplastic syndrome. Acta Derm Venereol, 2014;94;223-224.
    Pubmed
  5. Farah, C, Bulai Livideanu, C, Jegu, J, et al. Prevalence and prognostic value of cutaneous manifestations in patients with myelodysplastic syndrome. J Eur Acad Dermatol Venereol, 2010;24;1171-1175.
    Pubmed
  6. Avivi, I, Rosenbaum, H, Levy, Y, Rowe, J. Myelodysplastic syndrome and associated skin lesions: a review of the literature. Leuk Res, 1999;23;323-330.
    Pubmed
  7. Tyndall, A, Daikeler, T. Autologous hematopoietic stem cell transplantation for autoimmune diseases. Acta Haematol, 2005;114;239-247.
    Pubmed
  8. Bohgaki, T, Atsumi, T, Koike, T. Autoimmune disease after autologous hematopoietic stem cell transplantation. Autoimmun Rev, 2008;7;198-203.
    Pubmed
  9. Yamanaka, K, Kuniyuki, S, Maekawa, N, Yoshida, Y, Teshima, H. Pyoderma gangrenosum with myelodysplastic syndrome treated with analogous bone marrow transplantation. Acta Derm Venereol, 2009;89;105-106.
    Pubmed
  10. Haga, N, Iwata, H, Yamaguchi, Y, et al. Mucocutaneous pyoderma gangrenosum due to trisomy 8 neutrophilic infiltrates in a patient with myelodysplastic syndrome. Br J Dermatol, 2016;174;239-241.
    Pubmed

Article

Letter to the Editor

Blood Res 2017; 52(4): 319-321

Published online December 31, 2017 https://doi.org/10.5045/br.2017.52.4.319

Copyright © The Korean Society of Hematology.

Successful treatment of a patient with myelodysplastic syndrome accompanied by pyoderma gangrenosum and Behçet's disease using allogeneic stem cell transplantation

Seung-Shin Lee1, Jae-Sook Ahn1*, Sook Jung Yun2, and Dong-Jin Park3

1Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Korea.

2Department of Dermatology, Chonnam National University Hwasun Hospital, Hwasun, Korea.

3Division of Rheumatology, Chonnam National University Hwasun Hospital, Hwasun, Korea.

Correspondence to:Jae-Sook Ahn. Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, 322 Seoyangro, Hwasun-eup, Hwasun-gun, Jeonnam 58128, Korea. f0115@chonnam.ac.kr

Received: December 27, 2016; Revised: April 5, 2017; Accepted: May 25, 2017

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

    Fig 1.

    Figure 1.

    Presentation of clinical course after diagnosis of myelodysplastic syndrome (MDS). The facial granulomatous lesion at diagnosis (A), oral ulcer, suppurative ulcer on leg, and ulcerative lesion in ileum by colonoscopy (B). Improvement of the facial granulomatous lesion and leg ulcer after allogeneic stem cell transplantation (SCT) (C).

    Blood Research 2017; 52: 319-321https://doi.org/10.5045/br.2017.52.4.319

    References

    1. Komrokji, RS, Zhang, L, Bennett, JM. Myelodysplastic syndromes classification and risk stratification. Hematol Oncol Clin North Am, 2010;24;443-457.
      Pubmed
    2. Al Ustwani, O, Ford, LA, Sait, SJ, et al. Myelodysplastic syndromes and autoimmune diseases-case series and review of literature. Leuk Res, 2013;37;894-899.
      Pubmed
    3. Komrokji, RS, Kulasekararaj, A, Al Ali, NH, et al. Autoimmune diseases and myelodysplastic syndromes. Am J Hematol, 2016;91;E280-E283.
      Pubmed
    4. Hagiwara, A, Fujimura, T, Furudate, S, et al. Generalized granulomatous dermatitis accompanied by myelodysplastic syndrome. Acta Derm Venereol, 2014;94;223-224.
      Pubmed
    5. Farah, C, Bulai Livideanu, C, Jegu, J, et al. Prevalence and prognostic value of cutaneous manifestations in patients with myelodysplastic syndrome. J Eur Acad Dermatol Venereol, 2010;24;1171-1175.
      Pubmed
    6. Avivi, I, Rosenbaum, H, Levy, Y, Rowe, J. Myelodysplastic syndrome and associated skin lesions: a review of the literature. Leuk Res, 1999;23;323-330.
      Pubmed
    7. Tyndall, A, Daikeler, T. Autologous hematopoietic stem cell transplantation for autoimmune diseases. Acta Haematol, 2005;114;239-247.
      Pubmed
    8. Bohgaki, T, Atsumi, T, Koike, T. Autoimmune disease after autologous hematopoietic stem cell transplantation. Autoimmun Rev, 2008;7;198-203.
      Pubmed
    9. Yamanaka, K, Kuniyuki, S, Maekawa, N, Yoshida, Y, Teshima, H. Pyoderma gangrenosum with myelodysplastic syndrome treated with analogous bone marrow transplantation. Acta Derm Venereol, 2009;89;105-106.
      Pubmed
    10. Haga, N, Iwata, H, Yamaguchi, Y, et al. Mucocutaneous pyoderma gangrenosum due to trisomy 8 neutrophilic infiltrates in a patient with myelodysplastic syndrome. Br J Dermatol, 2016;174;239-241.
      Pubmed
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