Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea.
A 73-year-old man with no past medical history transferred to Asan Medical Cener after being diagnosed with hydrocephalus resulted from recent dementia and falling down. Splenomegaly and multiple enlarged lymph nodes was found on computed tomography. His hemoglobin level was 8.6 g/dL; platelet count, 65×109/L; white blood cell count, 3.9×109/L; and mean corpuscular volume, 96.4 fL. A bone marrow (BM) aspirate revealed trilineage hematopoietic components with reactive plasmacytosis (plasma cells: 4.8% among BM nucleated cells). BM biopsy and clot section showed a normocellular marrow (40% cellularity) with multiple fibronodular and granulomatous lesions (
In a retrospective analysis based on patients with HL, CD15 negative patients had a higher incidence of relapse and a lower survival rate. But the other analysis failed to observe the prognostic role of CD15. The pathobiology of HL has been elucidated. EBV may play a role in the pathobiology of a significant fraction of HL cases.