The CISL evaluated the cytogenetic aberrations in the bone marrow (BM) of diffuse large B-cell lymphoma (DLBCL) patients [2] in a retrospective multicenter analysis of 1,585 newly diagnosed DLBCL patients. Isolated cytogenetic aberrations without histologic involvement were found in 21 patients (1.3%). Two or more cytogenetic abnormalities were associated with lower overall survival (OS). Isolated cytogenetic aberrations in the BM can indicate BM involvement, and cytogenetic evaluation of BM improves staging accuracy in addition to providing prognostic information for DLBCL patients.

We compared various chemo-mobilization regimens, e.g. high-dose (HD) cyclophosphamide, HD etoposide, and platinum-based chemotherapies [3]. HD etoposide mobilized a significantly higher number of CD34+ cells than the other 2 approaches, and the successful mobilization rate was also significantly higher with HD etoposide.

The clinical features of Waldeyer's ring (WR) NHL patients were analyzed [4]. DLBCL was the most common pathologic subtype, followed by peripheral T-cell lymphoma (PTCL) and extranodal NK/T-cell lymphoma (ENKTL). Age ≥62 years, T-cell subtype, and failure to achieve a complete response (CR) were significant risk factors.

We retrospectively analyzed 131 mantle cell lymphoma (MCL) patients [5]. Their median age was 63 years (range, 26-78 years; male, 77.9%). One hundred five patients had stage III or IV disease. Fifty-two patients were categorized as high- or high-intermediate risk by the International Prognostic Index (IPI). Eighteen patients were in the high-risk group by the simplified MCL-IPI (MIPI). Extranodal involvement was found in 69.5%, BM in 41.2%, and gastrointestinal tract in 35.1%. R-CHOP was a frequent first-line treatment (41.2%). Two-year OS was 64.7%, while the event-free survival (EFS) was 39.7%. The simplified MIPI was significantly associated with OS.

Twenty intraocular (IOL) patients were studied [6]. Four patients were diagnosed with IOL alone. Two patients later developed central nervous system (CNS) involvement. Nine patients developed CNS lesions before the onset of IOL. Five patients had simultaneous onset in the eye and CNS. Intravitreal injection of methotrexate and/or various combinations of systemic chemotherapy with or without radiotherapy were administered. The median progression-free survival (PFS) was 19.7 months and 3-year OS was 75.1%.

We evaluated the efficacy of hyper-CVAD induction and stem cell transplantation (SCT) consolidation in 49 lymphoblastic lymphoma (LBL) patients [7]. The overall response rate (ORR) was 79%: 73% CR and 6% partial response (PR). Among responders, 24 patients underwent autologous (N=16) or allogeneic SCT (N=8). Their 3-year OS and PFS were 76% and 78%, respectively. Fifteen patients without SCT consolidation showed poorer PFS. Hyper-CVAD is effective for remission induction in LBL, and SCT consolidation produced better clinical outcomes.

We evaluated the outcomes of 43 adult Burkitt lymphoma (BL) or Burkitt-like lymphoma patients with no human immunodeficiency virus infection who were treated with a rituximab plus hyper-CVAD (R-hyper-CVAD) regimen [8]. The 2-year EFS and OS were 70.9% and 81.4%, respectively. R-hyper-CVAD resulted in excellent outcomes.

We evaluated primary sinonasal DLBCL patients treated with R-CHOP [9]. Fifty-nine patients received R-CHOP alone, whereas 21 were followed by involved field radiotherapy. In patients with stage I–II disease, no difference was found in the response rate and OS between the two groups. Among 11 patients with relapses, the most common type was local (n=8), with a CNS relapse in 1. Patients with primary sinonasal DLBCL treated with R-CHOP have a low CNS relapse rate and better OS compared to previous studies that did not use rituximab.

We analyzed 210 localized stage marginal zone lymphoma (MZL) patients (stage I: 180, stage II: 30) to explore the role of additional chemotherapy [10]. Twenty-eight patients received additional chemotherapy. In the local treatment and additional chemotherapy group, the median PFS was 147 and 103 months, and the OS was 188 and 137 months, respectively. Localized stage MZL has a good clinical course and is well controlled with local treatment modality without additional chemotherapy.

We investigated repeated ¹³¹I-rituximab in B-cell lymphoma patients [11]. Thirty-one patients with relapsed or refractory (RR) B cell lymphoma received ¹³¹I-rituximab at 4 week intervals. Repeated radioimmunotherapy (RIT) yielded two-fold increases in the response rate (68%) and in the median response duration (8.6 months). This approach also induced a favorable response in cases of aggressive histology.

A phase I study of everolimus was performed as combination chemotherapy in PTCL [12]. Fifteen newly diagnosed stage III/IV PTCL patients were enrolled. The recommended dose of everolimus for combination chemotherapy was 5 mg. All evaluable patients achieved a response (8 CR and 6 PR). We concluded that everolimus (5 mg) can be safely combined with CHOP, leading to a feasible and effective regimen for PTCL.

We conducted a phase II trial of concurrent chemoradiotherapy (CCRT) followed by 2 cycles of VIDL for 30 patients with stages IE or IIE nasal ENKTL [13]. CCRT yielded a 90% ORR (CR: 20 patients); however, 2 patients developed distant disease progression. VIDL chemotherapy had a final 87% CR rate. The 5-year PFS and OS were 60% and 73%, respectively.

We tried 4 doses of weekly rituximab (375 mg/m²) consolidation after 4 cycles of R-CHOP-21 in DLBCL patients aged ≥70 years [14]. The median age was 76 years (range, 70-89 yrs). Of 51 patients, 41 completed the planned rituximab consolidation and the ORR was 78.4% (CR, 74.5%). Two-year PFS and OS were 63.9% and 68.7%, respectively. No serious toxicities were reported.

We investigated the gemcitabine, dexamethasone, and cisplatin (GDP) regimen for RR PTCLs [15]. Patients could proceed to autologous stem cell transplantation (ASCT) after 4 cycles of GDP or receive up to 6 treatment cycles. The diagnoses were PTCL-not otherwise specified in 14 and angioimmunoblastic T-cell lymphoma in 4. Twelve patients had a CR and 6 had a PR. Four patients proceeded to ASCT, and 3 patients achieved a CR. The median PFS was 9.3 months. GDP is a highly effective and optimal salvage regimen for RR PTCLs.