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Blood Res 2015; 50(2):
Published online June 25, 2015
https://doi.org/10.5045/br.2015.50.2.67
© The Korean Society of Hematology
Mesenchymal niche: the sensor and effector of leukemogenesis
The Catholic High-Performance Cell Therapy Center, The Catholic University of Korea, Seoul, Korea.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
REFERENCES
- Caplan, AI, Correa, D. The MSC: an injury drugstore. Cell Stem Cell, 2011;9;11-15.
- Sacchetti, B, Funari, A, Michienzi, S, et al. Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment. Cell, 2007;131;324-336.
- Oh, IH, Kwon, KR. Concise review: multiple niches for hematopoietic stem cell regulations. Stem Cells, 2010;28;1243-1249.
- Ishikawa, F, Yoshida, S, Saito, Y, et al. Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region. Nat Biotechnol, 2007;25;1315-1321.
- Colmone, A, Amorim, M, Pontier, AL, Wang, S, Jablonski, E, Sipkins, DA. Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cells. Science, 2008;322;1861-1865.
- Zhang, B, Ho, YW, Huang, Q, et al. Altered microenvironmental regulation of leukemic and normal stem cells in chronic myelogenous leukemia. Cancer Cell, 2012;21;577-592.
- Frisch, BJ, Ashton, JM, Xing, L, Becker, MW, Jordan, CT, Calvi, LM. Functional inhibition of osteoblastic cells in an in vivo mouse model of myeloid leukemia. Blood, 2012;119;540-550.
- Walkley, CR, Olsen, GH, Dworkin, S, et al. A microenvironmentinduced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency. Cell, 2007;129;1097-1110.
- Walkley, CR, Shea, JM, Sims, NA, Purton, LE, Orkin, SH. Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment. Cell, 2007;129;1081-1095.
- Kim, JA, Shim, JS, Lee, GY, et al. Microenvironmental remodeling as a parameter and prognostic factor of heterogeneous leukemogenesis in acute myelogenous leukemia. Cancer Res, 2015;75;2222-2231.
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Editorial
Blood Res 2015; 50(2): 67-68
Published online June 25, 2015 https://doi.org/10.5045/br.2015.50.2.67
Copyright © The Korean Society of Hematology.
Mesenchymal niche: the sensor and effector of leukemogenesis
Il-Hoan Oh, M.D. Ph.D.*
The Catholic High-Performance Cell Therapy Center, The Catholic University of Korea, Seoul, Korea.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
References
- Caplan, AI, Correa, D. The MSC: an injury drugstore. Cell Stem Cell, 2011;9;11-15.
- Sacchetti, B, Funari, A, Michienzi, S, et al. Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment. Cell, 2007;131;324-336.
- Oh, IH, Kwon, KR. Concise review: multiple niches for hematopoietic stem cell regulations. Stem Cells, 2010;28;1243-1249.
- Ishikawa, F, Yoshida, S, Saito, Y, et al. Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region. Nat Biotechnol, 2007;25;1315-1321.
- Colmone, A, Amorim, M, Pontier, AL, Wang, S, Jablonski, E, Sipkins, DA. Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cells. Science, 2008;322;1861-1865.
- Zhang, B, Ho, YW, Huang, Q, et al. Altered microenvironmental regulation of leukemic and normal stem cells in chronic myelogenous leukemia. Cancer Cell, 2012;21;577-592.
- Frisch, BJ, Ashton, JM, Xing, L, Becker, MW, Jordan, CT, Calvi, LM. Functional inhibition of osteoblastic cells in an in vivo mouse model of myeloid leukemia. Blood, 2012;119;540-550.
- Walkley, CR, Olsen, GH, Dworkin, S, et al. A microenvironmentinduced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency. Cell, 2007;129;1097-1110.
- Walkley, CR, Shea, JM, Sims, NA, Purton, LE, Orkin, SH. Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment. Cell, 2007;129;1081-1095.
- Kim, JA, Shim, JS, Lee, GY, et al. Microenvironmental remodeling as a parameter and prognostic factor of heterogeneous leukemogenesis in acute myelogenous leukemia. Cancer Res, 2015;75;2222-2231.
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