Case Report

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Blood Res 2013; 48(3):

Published online September 25, 2013

https://doi.org/10.5045/br.2013.48.3.222

© The Korean Society of Hematology

A case of myelodysplastic syndrome with marked eosinophilia showing favorable prognosis

Min Ji Kim, Sung Hwa Bae, A Jin Lee, and Sang Gyung Kim*

Department of Laboratory Medicine, Daegu Catholic University School of Medicine, Daegu, Korea.

Correspondence to : Correspondence to Sang Gyung Kim, M.D. Department of Laboratory Medicine, Daegu Catholic University School of Medicine, 33, Duryugongwon-ro 17-gil, Nam-gu, Daegu 705-718, Korea. Phone: +82-53-650-4145, Fax: +82-53-653-8672, sgkim@cu.ac.kr

Received: May 16, 2012; Revised: July 16, 2012; Accepted: July 1, 2013

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Myelodysplastic syndrome (MDS) with eosinophilia is a rare condition and has yet to be classified under the 2008 World Health Organization classification. However, reports have described the prognostic significance of chronic persistent eosinophilia in MDS. Here, we report a case of a 67-year-old woman who was admitted to the hospital in July 2007 with generalized weakness, dizziness, and dyspnea on exertion persisting for 5 years. In the initial investigation, eosinophilia (22.1%) in peripheral blood and an increased proportion of eosinophils (5.6%) in normocellular bone marrow with dysplastic megakaryocytes and erythroid cells were noted. Eosinophilia was continuously detected during follow-up over 3 years. In a second bone marrow examination in August 2010, hypercellular bone marrow with similar features was observed. These findings led to the diagnosis of MDS with chronic persistent eosinophilia. To increase awareness of the prognostic significance of MDS with chronic eosinophilia, here we report a slow-progressing case of MDS with chronic persistent eosinophilia lasting over 6 years.

Keywords Myelodysplastic syndrome, Eosinophilia, Prognosis

Article

Case Report

Blood Res 2013; 48(3): 222-225

Published online September 25, 2013 https://doi.org/10.5045/br.2013.48.3.222

Copyright © The Korean Society of Hematology.

A case of myelodysplastic syndrome with marked eosinophilia showing favorable prognosis

Min Ji Kim, Sung Hwa Bae, A Jin Lee, and Sang Gyung Kim*

Department of Laboratory Medicine, Daegu Catholic University School of Medicine, Daegu, Korea.

Correspondence to: Correspondence to Sang Gyung Kim, M.D. Department of Laboratory Medicine, Daegu Catholic University School of Medicine, 33, Duryugongwon-ro 17-gil, Nam-gu, Daegu 705-718, Korea. Phone: +82-53-650-4145, Fax: +82-53-653-8672, sgkim@cu.ac.kr

Received: May 16, 2012; Revised: July 16, 2012; Accepted: July 1, 2013

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Myelodysplastic syndrome (MDS) with eosinophilia is a rare condition and has yet to be classified under the 2008 World Health Organization classification. However, reports have described the prognostic significance of chronic persistent eosinophilia in MDS. Here, we report a case of a 67-year-old woman who was admitted to the hospital in July 2007 with generalized weakness, dizziness, and dyspnea on exertion persisting for 5 years. In the initial investigation, eosinophilia (22.1%) in peripheral blood and an increased proportion of eosinophils (5.6%) in normocellular bone marrow with dysplastic megakaryocytes and erythroid cells were noted. Eosinophilia was continuously detected during follow-up over 3 years. In a second bone marrow examination in August 2010, hypercellular bone marrow with similar features was observed. These findings led to the diagnosis of MDS with chronic persistent eosinophilia. To increase awareness of the prognostic significance of MDS with chronic eosinophilia, here we report a slow-progressing case of MDS with chronic persistent eosinophilia lasting over 6 years.

Keywords: Myelodysplastic syndrome, Eosinophilia, Prognosis

Fig 1.

Figure 1.

Bone marrow (BM) aspirate smears showing dyserythropoiesis (A), dysmegakaryopoiesis (B), and increased promyelocytes with eosinophilic granules (C) in the initial BM study performed in July 2007. At a follow-up examination in August 2012, a BM aspirate smear showed increased immature eosinophils in the promyelocyte stage (D) (Wright stain, ×1,000).

Blood Research 2013; 48: 222-225https://doi.org/10.5045/br.2013.48.3.222

Fig 2.

Figure 2.

High eosinophilia counts in peripheral blood were seen during the follow-up over 6 years (from July 2007 to June 2012).

Blood Research 2013; 48: 222-225https://doi.org/10.5045/br.2013.48.3.222
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