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Blood Res 2015; 50(2):

Published online June 25, 2015

https://doi.org/10.5045/br.2015.50.2.114

© The Korean Society of Hematology

Prevalent factor XII deficiency in cancer patients with isolated aPTT prolongation

Dong-Yeop Shin1*, Hyo-Rak Lee1, Hye Jin Kang1, Im Il Na1, Yoon Hwan Chang2, and Sung Hyun Yang1

Author Info. +

1Division of Hematology and Medical Oncology, Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological Sciences, Seoul, Korea.

2Department of Laboratory Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological Sciences, Seoul, Korea.

Correspondence to : Correspondence to Dong-Yeop Shin. Division of Hematology and Medical Oncology, Department of Internal Medicine, Korea Cancer Center Hospital, 75 Nowon-gil, Nowon-gu, Seoul 139-706, Korea. baramg@hanmail.net

Received: November 10, 2014; Revised: November 25, 2014; Accepted: May 18, 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

FIGURES

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Fig. 1.

Flowchart of patient selection. Abbreviation: aPTT, activated partial thromboplastin time.


TABLES

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Table. 1.Baseline characteristics.

Abbreviation: aPTT, activated partial thromboplastin time.
Table. 2.Results of coagulation factors of the intrinsic pathway.

Abbreviations: IQR, Interquartile range; vWF:Ag, von Willebrand factor antigen; vWF:RCo, von Willebrand factor ristocetin cofactor.

REFERENCES

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  1. Proctor, RR, Rapaport, SI. The partial thromboplastin time with kaolin. A simple screening test for first stage plasma clotting factor deficiencies. Am J Clin Pathol, 1961;36;212-219.
    Pubmed
  2. Kershaw, G, Orellana, D. Mixing tests: diagnostic aides in the investigation of prolonged prothrombin times and activated partial thromboplastin times. Semin Thromb Hemost, 2013;39;283-290.
    Pubmed
  3. Douketis, JD, Berger, PB, Dunn, AS, et al. The perioperative management of antithrombotic therapy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest, 2008;133;299S-339S.
    Pubmed
  4. Chng, WJ, Sum, C, Kuperan, P. Causes of isolated prolonged activated partial thromboplastin time in an acute care general hospital. Singapore Med J, 2005;46;450-456.
    Pubmed
  5. Kwon, MJ, Kim, HJ, Lee, KO, Jung, CW, Kim, SH. Molecular genetic analysis of Korean patients with coagulation factor XII deficiency. Blood Coagul Fibrinolysis, 2010;21;308-312.
    Pubmed
  6. Zeerleder, S, Schloesser, M, Redondo, M, et al. Reevaluation of the incidence of thromboembolic complications in congenital factor XII deficiency-a study on 73 subjects from 14 Swiss families. Thromb Haemost, 1999;82;1240-1246.
    Pubmed
  7. Dendrinos, S, Deliveliotou, A, Anastasiou, A, Creatsas, GK. Role of coagulation factor XII in unexplained recurrent abortions in the Greek population. J Reprod Med, 2014;59;56-62.
    Pubmed
  8. Kuhli, C, Scharrer, I, Koch, F, Ohrloff, C, Hattenbach, LO. Factor XII deficiency: a thrombophilic risk factor for retinal vein occlusion. Am J Ophthalmol, 2004;137;459-464.
    Pubmed
  9. Braulke, I, Pruggmayer, M, Melloh, P, Hinney, B, Köstering, H, Günther, E. Factor XII (Hageman) deficiency in women with habitual abortion: new subpopulation of recurrent aborters?. Fertil Steril, 1993;59;98-101.
    Pubmed

Article

Letter to the Editor

Blood Res 2015; 50(2): 114-117

Published online June 25, 2015 https://doi.org/10.5045/br.2015.50.2.114

Copyright © The Korean Society of Hematology.

Prevalent factor XII deficiency in cancer patients with isolated aPTT prolongation

Dong-Yeop Shin1*, Hyo-Rak Lee1, Hye Jin Kang1, Im Il Na1, Yoon Hwan Chang2, and Sung Hyun Yang1

1Division of Hematology and Medical Oncology, Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological Sciences, Seoul, Korea.

2Department of Laboratory Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological Sciences, Seoul, Korea.

Correspondence to: Correspondence to Dong-Yeop Shin. Division of Hematology and Medical Oncology, Department of Internal Medicine, Korea Cancer Center Hospital, 75 Nowon-gil, Nowon-gu, Seoul 139-706, Korea. baramg@hanmail.net

Received: November 10, 2014; Revised: November 25, 2014; Accepted: May 18, 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

    Fig 1.

    Download
    Figure 1.

    Flowchart of patient selection. Abbreviation: aPTT, activated partial thromboplastin time.

    Blood Research 2015; 50: 114-117https://doi.org/10.5045/br.2015.50.2.114
    Baseline characteristics.

    Abbreviation: aPTT, activated partial thromboplastin time..
    Results of coagulation factors of the intrinsic pathway.

    Abbreviations: IQR, Interquartile range; vWF:Ag, von Willebrand factor antigen; vWF:RCo, von Willebrand factor ristocetin cofactor..

    References

    1. Proctor, RR, Rapaport, SI. The partial thromboplastin time with kaolin. A simple screening test for first stage plasma clotting factor deficiencies. Am J Clin Pathol, 1961;36;212-219.
      Pubmed
    2. Kershaw, G, Orellana, D. Mixing tests: diagnostic aides in the investigation of prolonged prothrombin times and activated partial thromboplastin times. Semin Thromb Hemost, 2013;39;283-290.
      Pubmed
    3. Douketis, JD, Berger, PB, Dunn, AS, et al. The perioperative management of antithrombotic therapy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest, 2008;133;299S-339S.
      Pubmed
    4. Chng, WJ, Sum, C, Kuperan, P. Causes of isolated prolonged activated partial thromboplastin time in an acute care general hospital. Singapore Med J, 2005;46;450-456.
      Pubmed
    5. Kwon, MJ, Kim, HJ, Lee, KO, Jung, CW, Kim, SH. Molecular genetic analysis of Korean patients with coagulation factor XII deficiency. Blood Coagul Fibrinolysis, 2010;21;308-312.
      Pubmed
    6. Zeerleder, S, Schloesser, M, Redondo, M, et al. Reevaluation of the incidence of thromboembolic complications in congenital factor XII deficiency-a study on 73 subjects from 14 Swiss families. Thromb Haemost, 1999;82;1240-1246.
      Pubmed
    7. Dendrinos, S, Deliveliotou, A, Anastasiou, A, Creatsas, GK. Role of coagulation factor XII in unexplained recurrent abortions in the Greek population. J Reprod Med, 2014;59;56-62.
      Pubmed
    8. Kuhli, C, Scharrer, I, Koch, F, Ohrloff, C, Hattenbach, LO. Factor XII deficiency: a thrombophilic risk factor for retinal vein occlusion. Am J Ophthalmol, 2004;137;459-464.
      Pubmed
    9. Braulke, I, Pruggmayer, M, Melloh, P, Hinney, B, Köstering, H, Günther, E. Factor XII (Hageman) deficiency in women with habitual abortion: new subpopulation of recurrent aborters?. Fertil Steril, 1993;59;98-101.
      Pubmed
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