Blood Res 2015; 50(1):
Published online March 31, 2015
https://doi.org/10.5045/br.2015.50.1.58
© The Korean Society of Hematology
1Department of Laboratory Medicine & Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
2Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Correspondence to : Hee-Jin Kim, Sun-Hee Kim. Department of Laboratory Medicine & Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81, Irwon-ro, Gangnam-gu, Seoul 135-710, Korea. heejinkim@skku.edu, sunnyhk@skku.edu
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
The first case, 27-year-old man was referred to our hospital for a dyspnea workup. The echocardiogram revealed severe tricuspid valve regurgitation and moderate mitral valve regurgitation. A valvuloplasty was performed and dizziness developed after the surgery. Brain magnetic resonance imaging revealed microbleeding in the right temporo-occipital lobe. He was referred to the hemato-oncology department for evaluation of eosinophilia. The laboratory findings were as follows: WBC count, 21.1×109/L (eosinophil count, 13.0×109/L); Hb, 9.1 g/dL; and platelet count, 99.0×109/L. In addition, parasite antibodies for
The second case, 23-year-old man was referred to our hospital for a workup as eosinophilia had been detected in a routine health checkup. The laboratory findings were as follows: WBC count, 70.0×109/µL (eosinophil count, 55.3×109/L); Hb, 10.1 g/dL; and platelet count, 131.0×109/L. The number of eosinophils in the peripheral blood smear was increased (Fig. 1C). In the bone marrow aspirate, 90% of all nucleated cells were eosinophils. Infiltration by eosinophils was observed in the bone marrow section (Fig. 1D). Conventional cytogenetic analysis revealed a normal karyotype (46,XY) and FISH for
The
The initial clinical manifestation of HES involves dermatologic, pulmonary, and gastrointestinal symptoms [10]. However, the presence of neurologic or cardiac signs and symptoms increases with disease progression or delayed diagnosis [10]. Severe cardiac complications include endomyocardial fibrosis, valve scarring, and embolism. Our patients also showed dyspnea, cardiac signs (valve regurgitation), and renal involvement (Case 1). Therefore, clinicians need to be alert for the presence
In conclusion, we report 2 cases of CEL with the
Peripheral blood (PB) smear and bone marrow (BM) aspirate findings of first case
Fluorescence in situ hybridization (FISH) for the FIP1L1-PDGFRA rearrangement, and reverse transcription - polymerase chain reaction (RT-PCR) and sequencing analysis.
Table 1 Summary of Korean cases with PDGFRA/PDGRB or FGFR1 abnormalities.
Abbreviations: AMML, acute myelomonocytic leukemia; CEL, chronic eosinophilic leukemia; CMML, chronic myelomonocytic leukemia; MD, minimal differentiation; MM, multiple myeloma; NA, not available.
Blood Res 2015; 50(1): 58-61
Published online March 31, 2015 https://doi.org/10.5045/br.2015.50.1.58
Copyright © The Korean Society of Hematology.
Sang-Yong Shin1, Chul-Won Jung2, Dong-Chull Choi2, Byung-Jae Lee2, Hee-Jin Kim1*, and Sun-Hee Kim1*
1Department of Laboratory Medicine & Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
2Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Correspondence to: Hee-Jin Kim, Sun-Hee Kim. Department of Laboratory Medicine & Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81, Irwon-ro, Gangnam-gu, Seoul 135-710, Korea. heejinkim@skku.edu, sunnyhk@skku.edu
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
The first case, 27-year-old man was referred to our hospital for a dyspnea workup. The echocardiogram revealed severe tricuspid valve regurgitation and moderate mitral valve regurgitation. A valvuloplasty was performed and dizziness developed after the surgery. Brain magnetic resonance imaging revealed microbleeding in the right temporo-occipital lobe. He was referred to the hemato-oncology department for evaluation of eosinophilia. The laboratory findings were as follows: WBC count, 21.1×109/L (eosinophil count, 13.0×109/L); Hb, 9.1 g/dL; and platelet count, 99.0×109/L. In addition, parasite antibodies for
The second case, 23-year-old man was referred to our hospital for a workup as eosinophilia had been detected in a routine health checkup. The laboratory findings were as follows: WBC count, 70.0×109/µL (eosinophil count, 55.3×109/L); Hb, 10.1 g/dL; and platelet count, 131.0×109/L. The number of eosinophils in the peripheral blood smear was increased (Fig. 1C). In the bone marrow aspirate, 90% of all nucleated cells were eosinophils. Infiltration by eosinophils was observed in the bone marrow section (Fig. 1D). Conventional cytogenetic analysis revealed a normal karyotype (46,XY) and FISH for
The
The initial clinical manifestation of HES involves dermatologic, pulmonary, and gastrointestinal symptoms [10]. However, the presence of neurologic or cardiac signs and symptoms increases with disease progression or delayed diagnosis [10]. Severe cardiac complications include endomyocardial fibrosis, valve scarring, and embolism. Our patients also showed dyspnea, cardiac signs (valve regurgitation), and renal involvement (Case 1). Therefore, clinicians need to be alert for the presence
In conclusion, we report 2 cases of CEL with the
Peripheral blood (PB) smear and bone marrow (BM) aspirate findings of first case
Fluorescence in situ hybridization (FISH) for the FIP1L1-PDGFRA rearrangement, and reverse transcription - polymerase chain reaction (RT-PCR) and sequencing analysis.
Table 1 . Summary of Korean cases with PDGFRA/PDGRB or FGFR1 abnormalities..
Abbreviations: AMML, acute myelomonocytic leukemia; CEL, chronic eosinophilic leukemia; CMML, chronic myelomonocytic leukemia; MD, minimal differentiation; MM, multiple myeloma; NA, not available..
Peripheral blood (PB) smear and bone marrow (BM) aspirate findings of first case
Fluorescence in situ hybridization (FISH) for the FIP1L1-PDGFRA rearrangement, and reverse transcription - polymerase chain reaction (RT-PCR) and sequencing analysis.