Letter to the Editor

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Blood Res 2014; 49(4):

Published online December 31, 2014

https://doi.org/10.5045/br.2014.49.4.279

© The Korean Society of Hematology

Tumor flare reaction in a patient with mantle cell lymphoma

Yusuf Kayar1*, and Nuket Bayram Kayar2

1Bezmialem Vakif University, Department of Internal Medicine, Istanbul, Turkey.

2Bagcilar Education & Research Hospital, Department of Family Medicine, Istanbul, Turkey.

Correspondence to : Yusuf Kayar. BezmialemVakif University, Department of Internal Medicine, Vatan Street, Fatih, Istanbul 34093, Turkey. ykayar@yahoo.com

Received: June 27, 2014; Revised: November 14, 2014; Accepted: November 19, 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Fig. 1.

The patient's throat magnetic resonance imaging scan showing a heterogeneously dense mass, sized approximately 65×29 mm at its broadest point, with its borders not clearly identified; therefore, the mass caused distinct asymmetry in the hypopharynx and oropharynx, displaced the uvula to the right side, and continued to the epiglottis level.


  1. Andritsos, LA, Johnson, AJ, Lozanski, G, et al. Higher doses of lenalidomide are associated with unacceptable toxicity including life-threatening tumor flare in patients with chronic lymphocytic leukemia. J Clin Oncol, 2008;26;2519-2525.
    Pubmed
  2. Chanan-Khan, A, Miller, KC, Musial, L, et al. Clinical efficacy of lenalidomide in patients with relapsed or refractory chronic lymphocytic leukemia: results of a phase II study. J Clin Oncol, 2006;24;5343-5349.
    Pubmed
  3. Ferrajoli, A, Lee, BN, Schlette, EJ, et al. Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia. Blood, 2008;111;5291-5297.
    Pubmed
  4. Corazzelli, G, De Filippi, R, Capobianco, G, et al. Tumor flare reactions and response to lenalidomide in patients with refractory classic Hodgkin lymphoma. Am J Hematol, 2010;85;87-90.
    Pubmed
  5. Eve, HE, Rule, SA. Lenalidomide-induced tumour flare reaction in mantle cell lymphoma. Br J Haematol, 2010;151;410-412.
    Pubmed

Article

Letter to the Editor

Blood Res 2014; 49(4): 279-280

Published online December 31, 2014 https://doi.org/10.5045/br.2014.49.4.279

Copyright © The Korean Society of Hematology.

Tumor flare reaction in a patient with mantle cell lymphoma

Yusuf Kayar1*, and Nuket Bayram Kayar2

1Bezmialem Vakif University, Department of Internal Medicine, Istanbul, Turkey.

2Bagcilar Education & Research Hospital, Department of Family Medicine, Istanbul, Turkey.

Correspondence to: Yusuf Kayar. BezmialemVakif University, Department of Internal Medicine, Vatan Street, Fatih, Istanbul 34093, Turkey. ykayar@yahoo.com

Received: June 27, 2014; Revised: November 14, 2014; Accepted: November 19, 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

    Fig 1.

    Figure 1.

    The patient's throat magnetic resonance imaging scan showing a heterogeneously dense mass, sized approximately 65×29 mm at its broadest point, with its borders not clearly identified; therefore, the mass caused distinct asymmetry in the hypopharynx and oropharynx, displaced the uvula to the right side, and continued to the epiglottis level.

    Blood Research 2014; 49: 279-280https://doi.org/10.5045/br.2014.49.4.279

    References

    1. Andritsos, LA, Johnson, AJ, Lozanski, G, et al. Higher doses of lenalidomide are associated with unacceptable toxicity including life-threatening tumor flare in patients with chronic lymphocytic leukemia. J Clin Oncol, 2008;26;2519-2525.
      Pubmed
    2. Chanan-Khan, A, Miller, KC, Musial, L, et al. Clinical efficacy of lenalidomide in patients with relapsed or refractory chronic lymphocytic leukemia: results of a phase II study. J Clin Oncol, 2006;24;5343-5349.
      Pubmed
    3. Ferrajoli, A, Lee, BN, Schlette, EJ, et al. Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia. Blood, 2008;111;5291-5297.
      Pubmed
    4. Corazzelli, G, De Filippi, R, Capobianco, G, et al. Tumor flare reactions and response to lenalidomide in patients with refractory classic Hodgkin lymphoma. Am J Hematol, 2010;85;87-90.
      Pubmed
    5. Eve, HE, Rule, SA. Lenalidomide-induced tumour flare reaction in mantle cell lymphoma. Br J Haematol, 2010;151;410-412.
      Pubmed
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