A case of chronic myeloid leukemia with features of essential thrombocythemia in peripheral blood and bone marrow

Young Jae Byun; Byeong-Bae Park; Eun Sung Lee; Kyung Soo Choi; Dae Sung Lee

doi:10.5045/br.2014.49.2.127

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Blood Res 2014; 49(2):

Published online June 25, 2014

https://doi.org/10.5045/br.2014.49.2.127

A case of chronic myeloid leukemia with features of essential thrombocythemia in peripheral blood and bone marrow

Young Jae Byun, Byeong-Bae Park^*, Eun Sung Lee, Kyung Soo Choi, and Dae Sung Lee

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Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.

Correspondence to : Correspondence to Byeong-Bae Park, M.D. Department of Internal Medicine, Hanyang University College of Medicine, 222, Wangsimni-ro, Seongdong-gu, Seoul 133-791, Korea. Tel: +82-2-2290-8335, Fax: +82-2-2298-9183, bbpark@hanyang.ac.kr

Received: July 27, 2012; Revised: September 19, 2012; Accepted: May 8, 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

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Abstract

Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by overproduction of myeloid white blood cells. Philadelphia chromosome is an essential finding for CML diagnosis. Generally, a clinical diagnosis of essential thrombocythemia (ET) can be established from isolated marked thrombocytosis in peripheral blood. However, Philadelphia chromosome-positivity or bcr/abl rearrangement with isolated thrombocytosis should be diagnosed as CML, not ET, according to World Health Organization diagnostic criteria. Therefore, CML should not be excluded before confirming the presence of the Philadelphia chromosome or bcr/abl rearrangement in cases of isolated thrombocytosis in peripheral blood. We report a case of CML with clinical features of ET in a patient successfully treated with imatinib.

Keywords Chronic myeloid leukemia, Philadelphia chromosome, Essential thrombocythemia

Article

Case Report

Blood Res 2014; 49(2): 127-129

Published online June 25, 2014 https://doi.org/10.5045/br.2014.49.2.127

A case of chronic myeloid leukemia with features of essential thrombocythemia in peripheral blood and bone marrow

Young Jae Byun, Byeong-Bae Park^*, Eun Sung Lee, Kyung Soo Choi, and Dae Sung Lee

Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.

Correspondence to: Correspondence to Byeong-Bae Park, M.D. Department of Internal Medicine, Hanyang University College of Medicine, 222, Wangsimni-ro, Seongdong-gu, Seoul 133-791, Korea. Tel: +82-2-2290-8335, Fax: +82-2-2298-9183, bbpark@hanyang.ac.kr

Received: July 27, 2012; Revised: September 19, 2012; Accepted: May 8, 2014

Abstract

Keywords: Chronic myeloid leukemia, Philadelphia chromosome, Essential thrombocythemia

Abstract

Fig 1.

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Figure 1.

Thrombocytosis without obvious morphologic abnormalities of the white blood cells and erythrocytes in peripheral blood smear (Wright Giemsa stain, ×400).

Blood Research 2014; 49: 127-129https://doi.org/10.5045/br.2014.49.2.127

Fig 2.

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Figure 2.

Bone marrow core biopsy sample showing hypercellular bone marrow for age with expanded myelopoiesis and small megakaryocytes with decreased nuclear lobation (H&E stain, ×200).

Blood Research 2014; 49: 127-129https://doi.org/10.5045/br.2014.49.2.127