Statistics of hematologic malignancies in Korea: incidence, prevalence and survival rates from 1999 to 2008

Hyeon Jin Park; Eun-Hye Park; Kyu-Won Jung; Hyun-Joo Kong; Young-Joo Won; Joo Young Lee; Jong Hyung Yoon; Byung-Kiu Park; Hyewon Lee; Hyeon-Seok Eom; Sohee Park

doi:10.5045/kjh.2012.47.1.28

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Original Article

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Korean J Hematol 2012; 47(1):

Published online March 31, 2012

https://doi.org/10.5045/kjh.2012.47.1.28

Statistics of hematologic malignancies in Korea: incidence, prevalence and survival rates from 1999 to 2008

Hyeon Jin Park¹, Eun-Hye Park², Kyu-Won Jung², Hyun-Joo Kong², Young-Joo Won², Joo Young Lee², Jong Hyung Yoon¹, Byung-Kiu Park¹, Hyewon Lee³, Hyeon-Seok Eom³, and Sohee Park^2*

Author Info. +

¹Center for Pediatric Oncology, National Cancer Center, Goyang, Korea.

²The Korea Central Cancer Registry, Division of Cancer Registration and Surveillance, National Cancer Center, Goyang, Korea.

³Center for Specific Organs Cancer, National Cancer Center, Goyang, Korea.

Correspondence to : Correspondence to Sohee Park, Ph.D. The Korea Central Cancer Registry, Division of Cancer Registration and Surveillance, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang 410-769, Korea. Tel: +82-31-920-2015, Fax: +82-31-920-2179, shpark@ncc.re.kr

Received: March 3, 2012; Revised: March 16, 2012; Accepted: March 19, 2012

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

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Abstract

Background

The nationwide statistical analysis of hematologic malignancies in Korea has not been reported yet.

Methods

The Korea Central Cancer Registry and the Korean Society of Hematology jointly investigated domestic incidence rates and prevalence of hematologic malignancies occurred between 1999 and 2008, and analyzed survival rates of patients who were diagnosed between 1993 and 2008. Data of hematologic malignancies from 1993 to 2008 were obtained from the Korean National Cancer Incidence Data base. The crude incidence rates, age-specific incidence rates, age-standardized incidence rates, annual percentage change of incidence, and prevalence from 1999-2008 were calculated. Survival rates for patients diagnosed in 1993-2008 were estimated.

Results

In 2008, a total of 8,006 cases of hematologic malignancies were occurred, which comprised 4.5% of all malignancies. In all genders, non-Hodgkin lymphoma, myeloid leukemia, and multiple myeloma were most frequent diseases. In terms of age, ages between 60 and 69 were most prevalent. From 1999 to 2008, the age-standardized incidence rates increased from 10.2 to 13.7, and the annual percentage change was 3.9%. The 5-year survival rate increased from 38.2% during 1993-1995 to 55.2% during 2004-2008. As of January 2009, number of patients with 10-year prevalence was 33,130, and with 5- to 10-year prevalence was 10,515.

Conclusion

This is the first nationwide statistical report of hematologic malignancies in Korea. It could be used as the basic information to help investigate epidemiologic characteristics, evaluate progress during the past years, and establish future strategies for hematologic malignancies. Periodic statistical analysis of hematologic malignancies in Korea should be continued.

Keywords Hematologic malignancy, Incidence, Survival, Prevalence, Korea

Article

Original Article

Korean J Hematol 2012; 47(1): 28-38

Published online March 31, 2012 https://doi.org/10.5045/kjh.2012.47.1.28

Statistics of hematologic malignancies in Korea: incidence, prevalence and survival rates from 1999 to 2008

Hyeon Jin Park¹, Eun-Hye Park², Kyu-Won Jung², Hyun-Joo Kong², Young-Joo Won², Joo Young Lee², Jong Hyung Yoon¹, Byung-Kiu Park¹, Hyewon Lee³, Hyeon-Seok Eom³, and Sohee Park^2*

¹Center for Pediatric Oncology, National Cancer Center, Goyang, Korea.

²The Korea Central Cancer Registry, Division of Cancer Registration and Surveillance, National Cancer Center, Goyang, Korea.

³Center for Specific Organs Cancer, National Cancer Center, Goyang, Korea.

Correspondence to: Correspondence to Sohee Park, Ph.D. The Korea Central Cancer Registry, Division of Cancer Registration and Surveillance, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang 410-769, Korea. Tel: +82-31-920-2015, Fax: +82-31-920-2179, shpark@ncc.re.kr

Received: March 3, 2012; Revised: March 16, 2012; Accepted: March 19, 2012

Abstract

Background

The nationwide statistical analysis of hematologic malignancies in Korea has not been reported yet.

Methods

Results

Conclusion

Keywords: Hematologic malignancy, Incidence, Survival, Prevalence, Korea

Abstract

Fig 1.

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Figure 1.

Relative frequency of hematologic malignancies in Korea, 2008. (A) Men. (B) Women.

Blood Research 2012; 47: 28-38https://doi.org/10.5045/kjh.2012.47.1.28

Fig 2.

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Figure 2.

Incident cases of hematologic malignancies by age group in Korea, 2008.

Blood Research 2012; 47: 28-38https://doi.org/10.5045/kjh.2012.47.1.28

Fig 3.

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Figure 3.

Age-specific incidence rates of hematologic malignancies in Korea, 2008. (A) Men. (B) Women.

Blood Research 2012; 47: 28-38https://doi.org/10.5045/kjh.2012.47.1.28

Fig 4.

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Figure 4.

Five-year survival rate of hematologic malignancies from 1993 to 2008 in Korea. ^a)Official registration employing ICD-O-3 began in 2003 at KCCR.

Blood Research 2012; 47: 28-38https://doi.org/10.5045/kjh.2012.47.1.28

Fig 5.

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Figure 5.

Number of prevalent cases of hematologic malignancies by time since diagnosis in January 1, 2009 in Korea. ^a)Because official registration for MPD and MDS began in 2003, 5-10 year prevalence cases for these cancers are underestimated.

Blood Research 2012; 47: 28-38https://doi.org/10.5045/kjh.2012.47.1.28

Table 1 . Classification of hematologic malignancies according to ICD-10..

Abbreviations: MPD, myeloproliferative disorders; MDS, myelodysplastic syndromes..

Table 2 . Ranks of age-specific incidence rates of hematologic malignancies by gender and age group in Korea, 2008..

Incidence rates per 100,000 are in parenthesis..

Abbreviations: LL, lymphoid leukemia; NHL, non-Hodgkin lymphoma; ML, myeloid leukemia; HL, Hodgkin lymphoma; MM, multiple myeloma; MPD, myeloproliferative disorders; MDS, myelodysplastic syndromes..

Table 3 . Number of hematologic malignancies and trend in crude incidence rates and age-standardized incidence rates in Korea from 1999 to 2008..

^a)Official registration employing ICD-O-3 began in 2003 at KCCR, ^b)The annual percent change is statistically significantly different from zero (P<0.05)..

Abbreviations: CR, crude incidence rate; ASR, age-standardized incidence rate; APC, annual percentage change; MPD, myeloproliferative disorders; MDS, myelodysplastic syndromes..

Table 4 . Five-year relative survival rates of hematologic malignancies by gender and age group in Korea..

^a)Change in the 5-year relative survival between 1993-1995 and 2004-2008 as a percentage, ^b)Official registration employing ICD-O-3 began in 2003 at KCCR..

Abbreviations: MPD, myeloproliferative disorders; MDS, myelodysplastic syndromes..

Table 5 . International comparison of age-standardized incidence rates of hematologic malignancies..

Age-standardized incidence rates using the WHO world standard population, for Korea, data are from Korea National Cancer Incidence Database (KNCI DB), for all other countries, data are from GLOBOCAN 2008..

^a)Multiple myeloma in Korea includes C90..