Korean J Hematol 2011; 46(1):
Published online March 31, 2011
https://doi.org/10.5045/kjh.2011.46.1.36
© The Korean Society of Hematology
1Department of Laboratory Medicine, CHA Bundang Medical Center, Seongnam, Korea.
2Department of Internal Medicine, CHA Bundang Medical Center, Seongnam, Korea.
3Department of Laboratory Medicine, CHA Kangnam Medical Center, Seoul, Korea.
Correspondence to : Correspondence to Ji Young Huh, M.D., Ph.D. Department of Laboratory Medicine, CHA Bundang Medical Center, CHA University, Yatap-dong, Bundang-gu, Sungnam 463-712, Korea. Tel: +82-31-780-5451, Fax: +82-31-780-5476, jiyoungh@cha.ac.kr
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Many infections are associated with antiphospholipid antibodies (aPLs). The purpose of this study was to investigate the prevalence, persistence, clinical significance, and characteristics of aPLs in hepatitis B virus (HBV)-infected patients.
This study included 143 patients with HBV infection and 32 healthy individuals as controls. The presence of anticardiolipin antibodies (aCL Ab), anti-β2-glycoprotein I antibodies (β2GPI Ab), and lupus anticoagulant (LA) was assessed.
The total prevalence of aPLs in HBV-infected patients was 12.6% (18 of 143). Of these 18 patients, 15 had low to medium titers of aCL Ab (10 with IgM, 4 with IgG, and 1 with both isotypes). β2GPI Ab and LA were detected in 3 (2.1%) and 2 (1.4%) patients with HBV infection, respectively. In follow-up specimens from 14 patients with elevated levels of aCL Ab or β2GPI Ab, 10 (71.4%) showed the persistent presence of aPLs. No clinical manifestations related to aPLs were identified.
In HBV-infected patients, the most frequently detected antiphospholipid antibodies were IgM aCL Ab, which have a weak association with the clinical manifestations of APS. Unlike the transient presence reported for other infection-associated aPLs, most aPLs were persistently detected over a 12-week period in patients with HBV infection.
Keywords Anticardiolipin antibodies, Anti-β2-glycoprotein I antibodies, Lupus coagulation inhibitor, Hepatitis B virus
Korean J Hematol 2011; 46(1): 36-40
Published online March 31, 2011 https://doi.org/10.5045/kjh.2011.46.1.36
Copyright © The Korean Society of Hematology.
Ji Young Huh1*, Dae Young Yi1, Seong Gyu Hwang2, Jin Jung Choi2, and Myung Seo Kang3
1Department of Laboratory Medicine, CHA Bundang Medical Center, Seongnam, Korea.
2Department of Internal Medicine, CHA Bundang Medical Center, Seongnam, Korea.
3Department of Laboratory Medicine, CHA Kangnam Medical Center, Seoul, Korea.
Correspondence to: Correspondence to Ji Young Huh, M.D., Ph.D. Department of Laboratory Medicine, CHA Bundang Medical Center, CHA University, Yatap-dong, Bundang-gu, Sungnam 463-712, Korea. Tel: +82-31-780-5451, Fax: +82-31-780-5476, jiyoungh@cha.ac.kr
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Many infections are associated with antiphospholipid antibodies (aPLs). The purpose of this study was to investigate the prevalence, persistence, clinical significance, and characteristics of aPLs in hepatitis B virus (HBV)-infected patients.
This study included 143 patients with HBV infection and 32 healthy individuals as controls. The presence of anticardiolipin antibodies (aCL Ab), anti-β2-glycoprotein I antibodies (β2GPI Ab), and lupus anticoagulant (LA) was assessed.
The total prevalence of aPLs in HBV-infected patients was 12.6% (18 of 143). Of these 18 patients, 15 had low to medium titers of aCL Ab (10 with IgM, 4 with IgG, and 1 with both isotypes). β2GPI Ab and LA were detected in 3 (2.1%) and 2 (1.4%) patients with HBV infection, respectively. In follow-up specimens from 14 patients with elevated levels of aCL Ab or β2GPI Ab, 10 (71.4%) showed the persistent presence of aPLs. No clinical manifestations related to aPLs were identified.
In HBV-infected patients, the most frequently detected antiphospholipid antibodies were IgM aCL Ab, which have a weak association with the clinical manifestations of APS. Unlike the transient presence reported for other infection-associated aPLs, most aPLs were persistently detected over a 12-week period in patients with HBV infection.
Keywords: Anticardiolipin antibodies, Anti-β2-glycoprotein I antibodies, Lupus coagulation inhibitor, Hepatitis B virus
Distribution of anticardiolipin antibody titers in hepatitis B virus (HBV)-infected patients and normal controls, IgM isotype
Table 1 . Prevalence of antiphospholipid antibodies (aCL Ab, β2GPI Ab, and lupus anticoagulant) in HBV-infected patients..
Abbreviations: HBV, hepatitis B virus; aCL Ab, anticardiolipin antibodies; β2GPI Ab, anti-β2-glycoprotein I antibodies..
Table 2 . Characteristics of HBV-infected patients with antiphospholipid antibodies and the types of antiphospholipid antibodies..
a)Patients were divided into 2 groups on the basis of the hepatitis B e antigen and antibody status and the HBV DNA level: chronic hepatitis B patients and patients with inactive HBsAg carrier state..
Abbreviations: HBV, hepatitis B virus; M, male; F, female; aCL, anticardiolipin antibodies; β2GPI, anti-β2-glycoprotein I antibodies; LA, lupus anticoagulant..
Table 3 . Follow-up duration and results of aCL Ab and β2GPI Ab testing in antiphospholipid antibody-positive HBV-infected patients..
a)Follow-up specimens of 3 patients (134, 140, and 153) could not be obtained..
Abbreviations: HBV, hepatitis B virus; aCL Ab, anticardiolipin antibodies; β2GPI Ab, anti-2-glycoprotein I antibodies; MPL, IgM phospholipid unit; GPL, IgG phospholipid unit; SMU, standard IgM unit; SGU, standard IgG unit;-, negative; NT, not tested..
Han Joo Kim and Dae‑Hyun Ko
Blood Res 2024; 59():Bo Ran Kwon, Jung Ha Mok, Jung Ho Bae, Hee Yun Seol, Young Mi Seol, Moo-Kon Song, Young Jin Choi, Ho Jin Shin, Joo Seop Chung, Goon Jae Cho
Korean J Hematol 2008; 43(2): 122-124
Distribution of anticardiolipin antibody titers in hepatitis B virus (HBV)-infected patients and normal controls, IgM isotype