Primary diffuse large B-cell lymphoma of the bone marrow in a frail and elderly patient successfully treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone

Pasquale Niscola; Massimiliano Palombi; Stefano Fratoni; Alessio Perrotti; Paolo de Fabritiis

doi:10.5045/br.2013.48.4.296

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Letter to the Editor

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Blood Res 2013; 48(4):

Published online December 31, 2013

https://doi.org/10.5045/br.2013.48.4.296

Primary diffuse large B-cell lymphoma of the bone marrow in a frail and elderly patient successfully treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone

Pasquale Niscola^1*, Massimiliano Palombi¹, Stefano Fratoni², Alessio Perrotti¹, and Paolo de Fabritiis¹

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¹Hematology Division, S. Eugenio Hospital, Rome, Italy.

²Department of Pathology, S. Eugenio Hospital, Rome, Italy.

Correspondence to : Pasquale Niscola. Hematology Division, S. Eugenio Hospital, Piazzale dell'Umanesimo 10, 00144, Rome, Italy. pniscola@gmail.com

Received: July 27, 2013; Revised: August 1, 2013; Accepted: November 21, 2013

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 1.

(A) Bone marrow biopsy (Giemsa stain, high magnification) showing a neoplastic infiltrate composed predominantly of blastic cells with centroblastic morphology, with minor components composed of small centrocyte-like cells. These findings are indicative of diffuse large B-cell lymphoma with features suggestive of a centrofollicular origin. (B) Immunostaining with CD20L26 antibodies reveals diffuse membrane expression in neoplastic cells. (C) Immunostaining with BCL2 reveals diffuse cytoplasmatic expression by neoplastic cells.

REFERENCES

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FIGURES
REFERENCES

Martinez, A, Ponzoni, M, Agostinelli, C, et al. Primary bone marrow lymphoma: an uncommon extranodal presentation of aggressive non-hodgkin lymphomas. Am J Surg Pathol, 2012;36;296-304.
Gudgin, E, Rashbass, J, Pulford, KJ, Erber, WN. Primary and isolated anaplastic large cell lymphoma of the bone marrow. Leuk Lymphoma, 2005;46;461-463.
Chang, H, Hung, YS, Lin, TL, et al. Primary bone marrow diffuse large B cell lymphoma: a case series and review. Ann Hematol, 2011;90;791-796.
Strauchen, JA. Primary bone marrow B-cell lymphoma: report of four cases. Mt Sinai J Med, 2003;70;133-138.
Kajiura, D, Yamashita, Y, Mori, N. Diffuse large B-cell lymphoma initially manifesting in the bone marrow. Am J Clin Pathol, 2007;127;762-769.
Hishizawa, M, Okamoto, K, Chonabayashi, K, Kaneko, H, Watanabe, M, Tsudo, M. Primary large B-cell lymphoma of the bone marrow. Br J Haematol, 2007;136;351.
Matthies, A, Schuster, SJ, Alavi, A. Staging and monitoring response to treatment in primary non-Hodgkin's lymphoma of bone marrow using (18)F-fluorodeoxyglucose positron emission tomography. Clin Lymphoma, 2001;1;303-306.
Kazama, H, Teramura, M, Yoshinaga, K, Masuda, A, Motoji, T. Long-term remission of primary bone marrow diffuse large B-cell lymphoma treated with high-dose chemotherapy rescued by in vivo rituximab-purged autologous stem cells. Case Rep Med, 2012;2012;957063.

Article

Letter to the Editor

Blood Res 2013; 48(4): 296-297

Published online December 31, 2013 https://doi.org/10.5045/br.2013.48.4.296

Primary diffuse large B-cell lymphoma of the bone marrow in a frail and elderly patient successfully treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone

Pasquale Niscola^1*, Massimiliano Palombi¹, Stefano Fratoni², Alessio Perrotti¹, and Paolo de Fabritiis¹

¹Hematology Division, S. Eugenio Hospital, Rome, Italy.

²Department of Pathology, S. Eugenio Hospital, Rome, Italy.

Correspondence to: Pasquale Niscola. Hematology Division, S. Eugenio Hospital, Piazzale dell'Umanesimo 10, 00144, Rome, Italy. pniscola@gmail.com

Received: July 27, 2013; Revised: August 1, 2013; Accepted: November 21, 2013

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Blood Research 2013; 48: 296-297https://doi.org/10.5045/br.2013.48.4.296

References

Martinez, A, Ponzoni, M, Agostinelli, C, et al. Primary bone marrow lymphoma: an uncommon extranodal presentation of aggressive non-hodgkin lymphomas. Am J Surg Pathol, 2012;36;296-304.
Gudgin, E, Rashbass, J, Pulford, KJ, Erber, WN. Primary and isolated anaplastic large cell lymphoma of the bone marrow. Leuk Lymphoma, 2005;46;461-463.
Chang, H, Hung, YS, Lin, TL, et al. Primary bone marrow diffuse large B cell lymphoma: a case series and review. Ann Hematol, 2011;90;791-796.
Strauchen, JA. Primary bone marrow B-cell lymphoma: report of four cases. Mt Sinai J Med, 2003;70;133-138.
Kajiura, D, Yamashita, Y, Mori, N. Diffuse large B-cell lymphoma initially manifesting in the bone marrow. Am J Clin Pathol, 2007;127;762-769.
Hishizawa, M, Okamoto, K, Chonabayashi, K, Kaneko, H, Watanabe, M, Tsudo, M. Primary large B-cell lymphoma of the bone marrow. Br J Haematol, 2007;136;351.
Matthies, A, Schuster, SJ, Alavi, A. Staging and monitoring response to treatment in primary non-Hodgkin's lymphoma of bone marrow using (18)F-fluorodeoxyglucose positron emission tomography. Clin Lymphoma, 2001;1;303-306.
Kazama, H, Teramura, M, Yoshinaga, K, Masuda, A, Motoji, T. Long-term remission of primary bone marrow diffuse large B-cell lymphoma treated with high-dose chemotherapy rescued by in vivo rituximab-purged autologous stem cells. Case Rep Med, 2012;2012;957063.