1Department of Laboratory Medicine, School of Medicine, Kyung Hee University, Seoul, Korea.
2Department of Pathology, School of Medicine, Kyung Hee University, Seoul, Korea.
3Department of Hematology-Oncology, School of Medicine, Kyung Hee University, Seoul, Korea.
A 30-year-old Korean man was admitted to our hospital due to left flank pain associated with ureter stone. Initial complete blood count (CBC) showed a hemoglobin (Hb) level of 11.9 g/dL (reference range, 13–17 g/dL) and a platelet count of 127,000/µL (reference range, 150,000–350,000/µL) with a white blood cell (WBC) count of 46,030/µL (reference range, 4,000–10,000/µL): 30.6% neutrophils, 7% lymphocytes, 3.9% monocytes, 55.7% eosinophils, and 1% basophils. Peripheral blood (PB) smear also showed increased number of eosinophils (Fig. 1A). Blood urine nitrogen (BUN) and creatinine levels were within reference ranges. Causes of eosinophilia due to allergy and parasite infections were excluded from further studies. Bone marrow examination was performed, showing hypercellular marrow with eosinophilic precursors, including mature eosinophils, being counting up to 36.2% (Fig. 1B). The chromosome study showed a normal karyotype; however, the
Within the distinct disease entity of myeloid and lymphoid neoplasms with eosinophilia and abnormalities of
Representative examples of ethnic differences among genetic abnormalities of hematologic malignancy include a higher incidence of acute promyelocytic leukemia in Chinese populations and the comparably low incidence of chronic lymphocytic leukemia among Asian ethnicity. Interestingly, most CEL cases with
Morphology in a patient of chronic eosinophilic leukemia with a
Fluorescence in situ hybridization (FISH) for the