Korean J Hematol 2001; 36(4):

Published online December 31, 2001

© The Korean Society of Hematology

호중구 산화물형성능 증가를 보인 만성호중구성백혈병 (Chronic Neutrophilic Leukemia) 1례

이나란히, 임석아, 이경은, 김도연, 남은미, 김성은, 이소현, 장지은A, 장지은B, 염문선, 염혜정, 권정미, 최영주, 성주명, 이순남, 서주영, 허희진, 정화순

이화여자대학교 의과대학 내과학교실,
이화여자대학교 의과대학 미생물학교실,
이화여자대학교 의과대학 임상병리학교실,

A Case of Chronic Neutrophilic Leukemia Associated with Increased Respiratiory Burst Activity of Neutrophils

Na Ran Hi Lee, Seock Ah Im, Kyung Eun Lee, Do Yeun Kim, Eun Mi Nam, Seong Eun Kim, So Hyeon Lee, Ji Eun Chang, Jee Eun Chang, Moon Sun Yeoum, Hae Jung Yeoum, Jung, Mi Kwon, Young, Ju Choi, Chu, Myoung Seong, Soon Nam Lee, Ju Young Seo, Hee, Jin Huh, Wha Soon Chung

Department of Internal Meidicine, Microbiology, Clinical Pathology, College of Medicine, Ewha Womans University, Seoul, Korea

Abstract

Chronic neutrophilic leukemia is a rare myeloproliferative disorder. We have experienced a typical case of chronic neutrophilic leukemia in a 76-year-old man who complained abdominal distension due to hepatosplenomegaly. White blood cell count of peripheral blood was 50,500/㎕ with 90% segmented neutrophils. The underlying disease for a leukemoid reaction had not been detected. Leukocyte alkaline phosphatase score and the serum levels of vitamin B 12 and uric acid were elevated.
Chromosome study showed a normal karyotype without Philadelphia chromosome or bcr/abl rearrangement. Phorbol myristate acetate-activated respiratory burst activity of neutrophils measured with chemiluminescence showed increased activity.

Keywords Chronic neutrophilic leukemia, Neutrophil, Increased respiratory burst

Article

Korean J Hematol 2001; 36(4): 359-363

Published online December 31, 2001

Copyright © The Korean Society of Hematology.

호중구 산화물형성능 증가를 보인 만성호중구성백혈병 (Chronic Neutrophilic Leukemia) 1례

이나란히, 임석아, 이경은, 김도연, 남은미, 김성은, 이소현, 장지은A, 장지은B, 염문선, 염혜정, 권정미, 최영주, 성주명, 이순남, 서주영, 허희진, 정화순

이화여자대학교 의과대학 내과학교실,
이화여자대학교 의과대학 미생물학교실,
이화여자대학교 의과대학 임상병리학교실,

A Case of Chronic Neutrophilic Leukemia Associated with Increased Respiratiory Burst Activity of Neutrophils

Na Ran Hi Lee, Seock Ah Im, Kyung Eun Lee, Do Yeun Kim, Eun Mi Nam, Seong Eun Kim, So Hyeon Lee, Ji Eun Chang, Jee Eun Chang, Moon Sun Yeoum, Hae Jung Yeoum, Jung, Mi Kwon, Young, Ju Choi, Chu, Myoung Seong, Soon Nam Lee, Ju Young Seo, Hee, Jin Huh, Wha Soon Chung

Department of Internal Meidicine, Microbiology, Clinical Pathology, College of Medicine, Ewha Womans University, Seoul, Korea

Abstract

Chronic neutrophilic leukemia is a rare myeloproliferative disorder. We have experienced a typical case of chronic neutrophilic leukemia in a 76-year-old man who complained abdominal distension due to hepatosplenomegaly. White blood cell count of peripheral blood was 50,500/㎕ with 90% segmented neutrophils. The underlying disease for a leukemoid reaction had not been detected. Leukocyte alkaline phosphatase score and the serum levels of vitamin B 12 and uric acid were elevated.
Chromosome study showed a normal karyotype without Philadelphia chromosome or bcr/abl rearrangement. Phorbol myristate acetate-activated respiratory burst activity of neutrophils measured with chemiluminescence showed increased activity.

Keywords: Chronic neutrophilic leukemia, Neutrophil, Increased respiratory burst

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