Korean J Hematol 1999; 34(1):
Published online March 31, 1999
© The Korean Society of Hematology
고근아, 강경령, 박지영, 조현찬, 박영석, 박찬정
한림대학교 의과대학 강동성심병원 임상병리과,
한림대학교 의과대학 강동섬심병원 내과,
울산대학교 의과대학 서울중앙병원 임상병리과
Background: The recent advances in flow cyromstric technology and the development of monoclonal antibodies have led to the important insights into the cell lineage and
maturation stage of leukemia. The increassd use of immunophenotyping in acute leukemla revealsd the unusual anigen expression and biclonal or biphenotypic acute
mixed lineage leukemia(AMLL). However, the data on their frequency and prognostic significance are still conflicting.
Methods: The immunophenotyping of leukemlc cells(HLA-OR, CD10, CDl9, CD20, CD22, CD3, CD5, CD7, CDl3, CD33, CD6l, TdT, cytoplasmic lg, surface lg) was performed by flow cytometry in 115 cases of acute leukemia between January 1994 and August 1996. Double-color immunofluorescent staining was peformsd in the cases expressing unusual antigens.
Results: 51 cases(44.3%) of 115 acute leukemias showed unusual antigens exprsssion.
These included 27 cases(38.6%) of 70 AML, 13 cases(43.3%) of 30 B-lineage ALL, 4 cases(50%) of 8 T-LL and 7 AMLL cases(6.l%) of 115 acute leukemias. CD7(28.6%) and CDl9(11.4%) are expressed in AML, and CDl3(36.7%) and CD33(26.7%) are expressed in ALL. Among 7 cases of AMLL, we could obtain the clinical data of 5 cases. The 4 cases of 5 AMLL failed to respond to induction chemotherapy or died before or during induction chemotherapy, and only one case showed partial remission.
Conclusion: The unusual antigen expressions of acute leuksmic cells are frequently observed, and the identification of relatively rare AMLL is very important, because AMLL showed poor response to the chemotherapy.
Keywords Acute leukemia, Immunophenotyping, Unusual antigen expression
Korean J Hematol 1999; 34(1): 52-61
Published online March 31, 1999
Copyright © The Korean Society of Hematology.
고근아, 강경령, 박지영, 조현찬, 박영석, 박찬정
한림대학교 의과대학 강동성심병원 임상병리과,
한림대학교 의과대학 강동섬심병원 내과,
울산대학교 의과대학 서울중앙병원 임상병리과
Guen A Ko, Chan Jeoung Park, Kyung Ryung Kang, Ji Young Park, Young Suk Park, Hyun Chan Cho
Department of Clinical Pathology, Internal Medicine, Hallym University College of Medicine, Seoul, Korea
Department of Clinical Pathology, Ulsan University College of Medicine, Korea
Background: The recent advances in flow cyromstric technology and the development of monoclonal antibodies have led to the important insights into the cell lineage and
maturation stage of leukemia. The increassd use of immunophenotyping in acute leukemla revealsd the unusual anigen expression and biclonal or biphenotypic acute
mixed lineage leukemia(AMLL). However, the data on their frequency and prognostic significance are still conflicting.
Methods: The immunophenotyping of leukemlc cells(HLA-OR, CD10, CDl9, CD20, CD22, CD3, CD5, CD7, CDl3, CD33, CD6l, TdT, cytoplasmic lg, surface lg) was performed by flow cytometry in 115 cases of acute leukemia between January 1994 and August 1996. Double-color immunofluorescent staining was peformsd in the cases expressing unusual antigens.
Results: 51 cases(44.3%) of 115 acute leukemias showed unusual antigens exprsssion.
These included 27 cases(38.6%) of 70 AML, 13 cases(43.3%) of 30 B-lineage ALL, 4 cases(50%) of 8 T-LL and 7 AMLL cases(6.l%) of 115 acute leukemias. CD7(28.6%) and CDl9(11.4%) are expressed in AML, and CDl3(36.7%) and CD33(26.7%) are expressed in ALL. Among 7 cases of AMLL, we could obtain the clinical data of 5 cases. The 4 cases of 5 AMLL failed to respond to induction chemotherapy or died before or during induction chemotherapy, and only one case showed partial remission.
Conclusion: The unusual antigen expressions of acute leuksmic cells are frequently observed, and the identification of relatively rare AMLL is very important, because AMLL showed poor response to the chemotherapy.
Keywords: Acute leukemia, Immunophenotyping, Unusual antigen expression
Seong Hyun Jeong, Hyun Woo Lee, Seok Yun Kang, Mi Sun Ahn, Yoon Ho Hwang, Jin Hyuk Choi, Hugh Chul Kim, Sung Ran Cho, Joon Seong Park
Korean J Hematol 2009; 44(2): 67-73Huyn Sik Choi, Ki Youn Kim, Joong Won Lee, Jang Soo Suh, Won Kil Lee, Jay Sik Kim, Dong Seok Jean
Korean J Hematol 1997; 32(1): 86-97Sun Och Yoon
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