A Case of Biphenotypic Acute Leukemia

S Y Yoon; J A Kwon; C K Lee; Y J Cho; Y G Kim; K N Lee

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Korean J Hematol 1992; 27(2):

Published online June 30, 1992

Biphenotypic Leukemia 1례

윤수영, 권정아, 이창규, 조윤정, 김영기, 이갑노

고려대학교 의과대학 임상병리학교실

A Case of Biphenotypic Acute Leukemia

S Y Yoon, J A Kwon, C K Lee, Y J Cho, Y G Kim, K N Lee

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Department of Clinical Patheology, College of Medicine, Korea University, Seoul, Korea

Abstract

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Abstract

Recently there has been considerable interest in acute leukemias with both myeloid and lymphoid features.
A 8-year-old girl with acute leukemia have blasts that expressed both lymphoid and myeloid markers. The morphology of the blasts is like FAB L2 but cytochemical
features such as Periodic acid-Schiff, Sudan black B and Myeloperoxidase do not meet the criteria of ALL. The wide overlap in the percentages of blasts expressing the
lymphoid marker(CD10) and myeloid marker(CDl3) indicates that most leukemic cells have both lineage markers. The leukemic cells also express the bone marrow progenitor
marker, CD34. The patient achieved remission with regimen for ALL.
We report this case as a biphenotypic leukemia with lymphoid and myeloid marker expression.

Keywords Leukemia, Biphenotypic