Korean J Hematol 2002; 37(1):
Published online March 31, 2002
© The Korean Society of Hematology
일정용량의 G-CSF를 사용한 고용량 항암화학요법시 조혈모세포의 가동과 생착에 관련된 인자
강석윤, 김재홍, 정성현, 신승수, 박준성, 김현수, 최진혁, 임호영, 김효철
아주대학교 의과대학 혈액종양내과학교실
Effect of Fixed Dose of G-CSF on Mobilization and Engraftment of Peripheral Blood Stem Cells in High Dose Chemotherapy
Background : Recently, the use of peripheral blood stem cell (PBSC) instead of bone marrow stem cells is associated with faster engraftment and reduced transplantation related complications. Several studies revealed that intermediate dose of Granulocyte-Colony Stimulating Factor (G-CSF) (less than 5 ㎍/㎏) is enough to be effective in the mobilization of stem cells for autologous transplantation. Also, to simplify mobilization procedure and reduce the cost for mobilization, a fixed
dose of G-CSF (250 ㎍/patient/day) needs to be tested for its clinical feasibility.
Methods : Patients with various malignant diseases were referred to the Ajou University Hospital (N=106) for PBSC transplantation with high dose chemotherapy. All
patients were given fixed dose of G-CSF (250㎍/patient/day) for mobilization and engraftment.
Results : Except for a few complaints of mild bone pain, all of the patients tolerated the treatment well during the mobilization. Early engraftment and yield of
mobilization were related to the accumulated cycle of prior chemotherapy and prior radiotherapy.
Conclusion : Fixed dose of G-CSF without accordance to the body weight of the patient showed no significant difference compared to the current reports on the mobilization of stem cells and engraftment after tansplantation. The total number of chemotherapy cycles exposed before transplantation and the prior radiation therapy history were certainly the most important influencing factor in stem cell transplantation and mobilzation.
Keywords Granulocyte-Colony Stimulating Factor(G-CSF);High dose chemotherapy;Autologous peripheral blood stem cell transplantation;
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Korean J Hematol 2002; 37(1): 24-30
Published online March 31, 2002
Copyright © The Korean Society of Hematology.
일정용량의 G-CSF를 사용한 고용량 항암화학요법시 조혈모세포의 가동과 생착에 관련된 인자
강석윤, 김재홍, 정성현, 신승수, 박준성, 김현수, 최진혁, 임호영, 김효철
아주대학교 의과대학 혈액종양내과학교실
Effect of Fixed Dose of G-CSF on Mobilization and Engraftment of Peripheral Blood Stem Cells in High Dose Chemotherapy
Seok Yun Kang, Jae Hong Kim, Seong Hyun Jeong, Seung Soo Sheen, Joon Seong Park, Hyun Soo Kim, Jin Hyuk Choi, Ho Yeong Lim, Hugh Chul Kim
Department of Hematology, oncology, College of Medicine, Ajou University Hospital, Suwon, Korea
Abstract
Background : Recently, the use of peripheral blood stem cell (PBSC) instead of bone marrow stem cells is associated with faster engraftment and reduced transplantation related complications. Several studies revealed that intermediate dose of Granulocyte-Colony Stimulating Factor (G-CSF) (less than 5 ㎍/㎏) is enough to be effective in the mobilization of stem cells for autologous transplantation. Also, to simplify mobilization procedure and reduce the cost for mobilization, a fixed
dose of G-CSF (250 ㎍/patient/day) needs to be tested for its clinical feasibility.
Methods : Patients with various malignant diseases were referred to the Ajou University Hospital (N=106) for PBSC transplantation with high dose chemotherapy. All
patients were given fixed dose of G-CSF (250㎍/patient/day) for mobilization and engraftment.
Results : Except for a few complaints of mild bone pain, all of the patients tolerated the treatment well during the mobilization. Early engraftment and yield of
mobilization were related to the accumulated cycle of prior chemotherapy and prior radiotherapy.
Conclusion : Fixed dose of G-CSF without accordance to the body weight of the patient showed no significant difference compared to the current reports on the mobilization of stem cells and engraftment after tansplantation. The total number of chemotherapy cycles exposed before transplantation and the prior radiation therapy history were certainly the most important influencing factor in stem cell transplantation and mobilzation.
Keywords: Granulocyte-Colony Stimulating Factor(G-CSF),High dose chemotherapy,Autologous peripheral blood stem cell transplantation,
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