Korean J Hematol 1996; 31(2):
Published online June 30, 1996
© The Korean Society of Hematology
t(15;17)과 idier(17)(q10)을 동반한 급성 전골수구성 백혈병 2례
김미나, 이유경, 이영준, 박성섭, 황치대, 조한익, 김병국, 조현찬
서울의대 임상병리과학교실,
서울의대 내과학교실,
한림의대 임상병리학교실
Two Cases of Acute Promyelocytic Leukemia with t(15;17) and ider(17) (q10)
In acute promyelocytic leukemia(APL), 1(15;17)(q22;q21) is considered as playing an essential role in the pathogenesis of APL through the rearrangement of the retinoic acid
receptor alpha(RARα) gene with the fat gene. We reported two patients with APL, who showed 15q+ and i(17q-) in cytogenetic analysis of the bone marrow In one of two
showed mosaicism of typical t(15;17), 15q+, i(17q-), and +der(21)t(3;21), and in another patient showed 15q+ and i(17q-) as sole abnormality. They revealed PML/RARα
rearrangement by reverse transcription PCR and hematological, cytogenetical, and molecular remission were accomplished by all-trans-retinoic acid(ATRA) and/or
cytotoxic chemotherapy.
Keywords Acute promyelocytic leukemia, ider(17)(q10)
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Korean J Hematol 1996; 31(2): 333-341
Published online June 30, 1996
Copyright © The Korean Society of Hematology.
t(15;17)과 idier(17)(q10)을 동반한 급성 전골수구성 백혈병 2례
김미나, 이유경, 이영준, 박성섭, 황치대, 조한익, 김병국, 조현찬
서울의대 임상병리과학교실,
서울의대 내과학교실,
한림의대 임상병리학교실
Two Cases of Acute Promyelocytic Leukemia with t(15;17) and ider(17) (q10)
Mee Na Kim, You Kyoung Lee, Young Jun Lee, Sung Sup Park, Chi Dae Hwang, Han lk Cho, Byoung Kook Kim, Hyoun Chan Cho
Department of Clinical Pathology, Internal Medicine, Seoul National University College of Medicine
Department of Clinical Pathology, College of Medicine, Hallym University
Abstract
In acute promyelocytic leukemia(APL), 1(15;17)(q22;q21) is considered as playing an essential role in the pathogenesis of APL through the rearrangement of the retinoic acid
receptor alpha(RARα) gene with the fat gene. We reported two patients with APL, who showed 15q+ and i(17q-) in cytogenetic analysis of the bone marrow In one of two
showed mosaicism of typical t(15;17), 15q+, i(17q-), and +der(21)t(3;21), and in another patient showed 15q+ and i(17q-) as sole abnormality. They revealed PML/RARα
rearrangement by reverse transcription PCR and hematological, cytogenetical, and molecular remission were accomplished by all-trans-retinoic acid(ATRA) and/or
cytotoxic chemotherapy.
Keywords: Acute promyelocytic leukemia, ider(17)(q10)
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