Review Article

Korean J Hematol 2007; 42(1):

Published online March 30, 2007

https://doi.org/10.5045/kjh.2007.42.1.15

© The Korean Society of Hematology

한국인 백혈병과 부조직적합항원 유전자형의 연관성

박민지, 최희백, 윤호열, 최은정, 김수연, 김희제, 엄기성, 이 석, 김동욱, 이종욱, 민우성, 김춘추, 김태규

가톨릭대학교 의과대학, 미생물학교실, 가톨릭조혈모세포은행, 가톨릭조혈모세포이식센터

Susceptibility of Leukemia according to the Genotype of Minor Histocompatibility Antigens in a Korean Population

Min Ji Park, Hee Baeg Choi, Ho Yeol Yoon, Eun Jeong Choi, Su Yeon Kim, Hee Je Kim, Ki Sung Eom, Seok Lee, Dong Wook Kim, Jong Wook Lee, Woo Sung Min, Chun Choo Kim, Tai Gyu Kim

Department of Microbiology, College of Medicine, Catholic Hematopoietic Stem Cell Bank
The Catholic Hematopoietic Stem Cell Transplantation Center, The Catholic University of Korea, Seoul, Korea

Abstract

Background:
In the search for susceptibility genes responsible for leukemia, genetic studies involving HLA association have been in progress extensively since the first report on its effect on the disease. Here we investigated the genetic associations of different leukemias with 4 autosomal mHags, HA-1, -2, -8 and HB-1. In particular, HB-1 is one of the leukemia-associated minor histocompatibility antigens (mHags) that is significantly expressed by Epstein-Barr virus-transformed- and tumor cells of all B lineage acute lymphoblastic leukemia (ALL).
Methods:
A simultaneous genotyping method using PCR sequence-specific primers against HA-1, -2, -8 and HB-1 was developed, and their allelic frequencies in 139 healthy controls and 36 leukemia patients were observed. To compare genotype, phenotype, and gene frequencies of mHags with healthy controls, leukemia patients were classified into sub groups of ALL, acute myeloid leukemia (AML), and chronic myeloid leukemia (CML).
Results:
The genotype frequencies of HA-1, -2 and -8 were not significantly different from healthy controls in every group of leukemia patients. However, the HB-1 H genotype was significantly increased in leukemia patients (P=0.03, OR=1.82, CI=1.08∼3.06), particularly in AML (P=0.01, OR=2.4, CI=1.21∼4.76) as compared with healthy controls.
Conclusion:
Our results suggested that the genotype of HB-1 H may be associated with leukemia, particularly with AML. In further study, it is necessary to confirm the association of HB-1 with other leukemias in a larger group of patients, and to identify the underlying mechanism of HB-1 responsible for the occurrence of leukemia.

Keywords Leukemia, Minor histocompatibility antigens, Korean

Article

Review Article

Korean J Hematol 2007; 42(1): 15-23

Published online March 30, 2007 https://doi.org/10.5045/kjh.2007.42.1.15

Copyright © The Korean Society of Hematology.

한국인 백혈병과 부조직적합항원 유전자형의 연관성

박민지, 최희백, 윤호열, 최은정, 김수연, 김희제, 엄기성, 이 석, 김동욱, 이종욱, 민우성, 김춘추, 김태규

가톨릭대학교 의과대학, 미생물학교실, 가톨릭조혈모세포은행, 가톨릭조혈모세포이식센터

Susceptibility of Leukemia according to the Genotype of Minor Histocompatibility Antigens in a Korean Population

Min Ji Park, Hee Baeg Choi, Ho Yeol Yoon, Eun Jeong Choi, Su Yeon Kim, Hee Je Kim, Ki Sung Eom, Seok Lee, Dong Wook Kim, Jong Wook Lee, Woo Sung Min, Chun Choo Kim, Tai Gyu Kim

Department of Microbiology, College of Medicine, Catholic Hematopoietic Stem Cell Bank
The Catholic Hematopoietic Stem Cell Transplantation Center, The Catholic University of Korea, Seoul, Korea

Abstract

Background:
In the search for susceptibility genes responsible for leukemia, genetic studies involving HLA association have been in progress extensively since the first report on its effect on the disease. Here we investigated the genetic associations of different leukemias with 4 autosomal mHags, HA-1, -2, -8 and HB-1. In particular, HB-1 is one of the leukemia-associated minor histocompatibility antigens (mHags) that is significantly expressed by Epstein-Barr virus-transformed- and tumor cells of all B lineage acute lymphoblastic leukemia (ALL).
Methods:
A simultaneous genotyping method using PCR sequence-specific primers against HA-1, -2, -8 and HB-1 was developed, and their allelic frequencies in 139 healthy controls and 36 leukemia patients were observed. To compare genotype, phenotype, and gene frequencies of mHags with healthy controls, leukemia patients were classified into sub groups of ALL, acute myeloid leukemia (AML), and chronic myeloid leukemia (CML).
Results:
The genotype frequencies of HA-1, -2 and -8 were not significantly different from healthy controls in every group of leukemia patients. However, the HB-1 H genotype was significantly increased in leukemia patients (P=0.03, OR=1.82, CI=1.08∼3.06), particularly in AML (P=0.01, OR=2.4, CI=1.21∼4.76) as compared with healthy controls.
Conclusion:
Our results suggested that the genotype of HB-1 H may be associated with leukemia, particularly with AML. In further study, it is necessary to confirm the association of HB-1 with other leukemias in a larger group of patients, and to identify the underlying mechanism of HB-1 responsible for the occurrence of leukemia.

Keywords: Leukemia, Minor histocompatibility antigens, Korean

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