Korean J Hematol 2006; 41(4):
Published online December 30, 2006
https://doi.org/10.5045/kjh.2006.41.4.297
© The Korean Society of Hematology
박남숙, 박상은, 천재민, 박남환, 양영준, 윤각원, 손은희, 윤환중, 조덕연, 송창준, 김삼용
충남대학교 의과대학, 내과학교실, 신경과학교실, 진단방사선과학교실
Limbic encephalitis is a rare neurological syndrome, which develops after stem cell transplantation, and is characterized by a series of neurological symptoms, including retrograde amnesia, behavioral disturbance, and progressive intellectual deterioration and high signal intensity in the hippocampus on magnetic resonance imaging (MRI). Herein is described the case of a patient with limbic encephalitis, which developed after allogeneic bone marrow transplantation, and was possibly due to HHV-6 infection. An 18-year-old man, with acute lymphoid leukemia, who underwent HLA-matched unrelated donor bone marrow transplantation, developed a fever and chill accompanied by neurological symptoms, including behavioral disturbance and retrograde amnesia, during the bone marrow recovery phase. A brain MRI revealed bright signal-intensity in both hippocampi. Examination of his cerebrospinal fluid suggested viral encephalitis. Based on these findings, a diagnosis of viral limbic encephalitis was highly suspected. Tests for casual causes of viral limbic encephalitis, including the CMV, HZV and HSV-1 and 2, in serum or CSF were all negative. The encephalitis responded well to ganciclovir therapy.
Keywords Limbic encephalitis, Allogeneic stem cell transplantation, HHV-6
Korean J Hematol 2006; 41(4): 297-301
Published online December 30, 2006 https://doi.org/10.5045/kjh.2006.41.4.297
Copyright © The Korean Society of Hematology.
박남숙, 박상은, 천재민, 박남환, 양영준, 윤각원, 손은희, 윤환중, 조덕연, 송창준, 김삼용
충남대학교 의과대학, 내과학교실, 신경과학교실, 진단방사선과학교실
Nam Sook Park, Sang Eun Park, Jae Min Chun, Nam Hwan Park, Yung Jun Yang, Kak Won Yun, Eun Hee Son, Hwan Jung Yun, Deog Yeon Jo, Chang Jun Song, Sam yong Kim
Departments of, Internal Medicine, Neurology, Radiology, College of Medicine, Chungnam National University, Daejeon, Korea
Limbic encephalitis is a rare neurological syndrome, which develops after stem cell transplantation, and is characterized by a series of neurological symptoms, including retrograde amnesia, behavioral disturbance, and progressive intellectual deterioration and high signal intensity in the hippocampus on magnetic resonance imaging (MRI). Herein is described the case of a patient with limbic encephalitis, which developed after allogeneic bone marrow transplantation, and was possibly due to HHV-6 infection. An 18-year-old man, with acute lymphoid leukemia, who underwent HLA-matched unrelated donor bone marrow transplantation, developed a fever and chill accompanied by neurological symptoms, including behavioral disturbance and retrograde amnesia, during the bone marrow recovery phase. A brain MRI revealed bright signal-intensity in both hippocampi. Examination of his cerebrospinal fluid suggested viral encephalitis. Based on these findings, a diagnosis of viral limbic encephalitis was highly suspected. Tests for casual causes of viral limbic encephalitis, including the CMV, HZV and HSV-1 and 2, in serum or CSF were all negative. The encephalitis responded well to ganciclovir therapy.
Keywords: Limbic encephalitis, Allogeneic stem cell transplantation, HHV-6
Seung-Ah Yahng, Jae-Ho Yoon, Seung-Hwan Shin, Sung-Eun Lee, Ki-Seong Eom, and Yoo-Jin Kim
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Korean J Hematol 2009; 44(4): 304-309Gak Won Yun, Ik Chan Song, Seon Ah Jin, Young Joon Yang, Nam Hwan Park, Hyo Jin Lee, Hwan Jung Yun, Sam yong Kim, Deog Yeon Jo
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