Korean J Hematol 1994; 29(3):
Published online September 30, 1994
© The Korean Society of Hematology
Pseudohyperphosphatemia를 보인 다발성 골수종 1례
김경숙, 김덕언, 이웅수, 정화순
한양대학교 의과대학 임상병리학교실,
이화여자대학교 의과대학부속 목동병원 임상병리과
Pseudohyperphosphatemia in Multiple Myeloma
Unexplained hyperphosphatemia was noted in a patient diagnosed as IgG-lambda type multiple myeloma. In this patient, the serum inorganic phosphate level was 2.3mmol/L(7.1㎎/dL) on the Technicon CHEM1TM. But the serum inorganic phosphate level was 1.4mmol/L(4.2㎎/dL) on the Hitachi 736TM and 1.5mmol/L(4.6㎎/dL) on CHEM1 TM after removal of the paraprotein by
ultrafiltration. These findings suggested that monoclonal proteins interfere in measurement of inorganic phosphate by colorimetric method. Our case demonstrated the
possibility that hyperphosphatemia in multiple myeloma may be due to the bindings of phosphate to monoclonal immunoglobulins.
Keywords Pseudohyperphosphatemia; Multiple myeloma;
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Korean J Hematol 1994; 29(3): 351-355
Published online September 30, 1994
Copyright © The Korean Society of Hematology.
Pseudohyperphosphatemia를 보인 다발성 골수종 1례
김경숙, 김덕언, 이웅수, 정화순
한양대학교 의과대학 임상병리학교실,
이화여자대학교 의과대학부속 목동병원 임상병리과
Pseudohyperphosphatemia in Multiple Myeloma
Kyung Suk Kim, Deog Un Kim, Wong Soo Lee, Wha Soon Chung
Department of Clinical Pathology, College of Medicine, Hanyang University
Ewha Womans University Mokdong Hospital, Seoul, Korea
Abstract
Unexplained hyperphosphatemia was noted in a patient diagnosed as IgG-lambda type multiple myeloma. In this patient, the serum inorganic phosphate level was 2.3mmol/L(7.1㎎/dL) on the Technicon CHEM1TM. But the serum inorganic phosphate level was 1.4mmol/L(4.2㎎/dL) on the Hitachi 736TM and 1.5mmol/L(4.6㎎/dL) on CHEM1 TM after removal of the paraprotein by
ultrafiltration. These findings suggested that monoclonal proteins interfere in measurement of inorganic phosphate by colorimetric method. Our case demonstrated the
possibility that hyperphosphatemia in multiple myeloma may be due to the bindings of phosphate to monoclonal immunoglobulins.
Keywords: Pseudohyperphosphatemia, Multiple myeloma,
