Korean J Hematol 1993; 28(2):
Published online June 30, 1993
© The Korean Society of Hematology
급성 백혈병에서 혈청내 Soluble IL-2 Receptor 측정
김시찬, 민유홍, 이선주, 한지숙, 고윤웅
연세대학교 의과대학 내과학교실
Evaluation of Serum Levels of Soluble Interleukin-2 Receptor in Patients with Acute Leukemia
Background: Soluble IL-2 receptor(sIL-2R) are released from activated human lymphoid cells in vitro, and markedly elevated levels of serum interleukin-2 receptor have recently been reported in patients with hematologic malignancies and autoimmune disorders. Previous reports have clarified a wide range of IL-2 recpetor expression in a
variety of non-T-cell hematopoietic neoplasm such as common acute lymphoblastic leukemia(ALL) and acute myelocytic leukemia(AML). In this study, we measure sIL-2R levels in acute leukemia and investigate the relationship between the levels of sIL-2R and clinical outcomes.
Methods: Soluble IL-2R was measured in 22 adults with acute leukemia using sandwich enzyme immuncassay available as the CELLFREE interleukin-2 Receptor Test Kit. Serial monitoring of soluble IL-2R could be possible in 18 cases.
Results: Serum levels of sIL-2R were significantly increased in patients with AML(mean, 1,507U/ml), and in patients with ALL(mean, 1,696U/ml) with respect to
controls(mean, 222U/ml; p<0.01). The levels of sIL-2R seemed to be related to the status of disease, decreased upon complete remission, and increased in relapsed cases.
Also there seemed to be negative correlation between serum IL-2R level evaluated on complete remission and complete remission duration in cases with ALL.
Conclusion: We conclude that the determination of level of soluble IL-2R in patients with acute leukemia might be regarded as an additional useful tool for monitoring
leukemic status. Understanding the biologic significance of soluble IL-2R in acute leukemia will be required.
Keywords Soluble IL-2 receptor; Acute leukemia;
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Korean J Hematol 1993; 28(2): 299-305
Published online June 30, 1993
Copyright © The Korean Society of Hematology.
급성 백혈병에서 혈청내 Soluble IL-2 Receptor 측정
김시찬, 민유홍, 이선주, 한지숙, 고윤웅
연세대학교 의과대학 내과학교실
Evaluation of Serum Levels of Soluble Interleukin-2 Receptor in Patients with Acute Leukemia
Si Chan Kim, Yoo Hong Min, Sun Ju Lee, Jee Sook Hahn, Yun Woong Ko
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
Abstract
Background: Soluble IL-2 receptor(sIL-2R) are released from activated human lymphoid cells in vitro, and markedly elevated levels of serum interleukin-2 receptor have recently been reported in patients with hematologic malignancies and autoimmune disorders. Previous reports have clarified a wide range of IL-2 recpetor expression in a
variety of non-T-cell hematopoietic neoplasm such as common acute lymphoblastic leukemia(ALL) and acute myelocytic leukemia(AML). In this study, we measure sIL-2R levels in acute leukemia and investigate the relationship between the levels of sIL-2R and clinical outcomes.
Methods: Soluble IL-2R was measured in 22 adults with acute leukemia using sandwich enzyme immuncassay available as the CELLFREE interleukin-2 Receptor Test Kit. Serial monitoring of soluble IL-2R could be possible in 18 cases.
Results: Serum levels of sIL-2R were significantly increased in patients with AML(mean, 1,507U/ml), and in patients with ALL(mean, 1,696U/ml) with respect to
controls(mean, 222U/ml; p<0.01). The levels of sIL-2R seemed to be related to the status of disease, decreased upon complete remission, and increased in relapsed cases.
Also there seemed to be negative correlation between serum IL-2R level evaluated on complete remission and complete remission duration in cases with ALL.
Conclusion: We conclude that the determination of level of soluble IL-2R in patients with acute leukemia might be regarded as an additional useful tool for monitoring
leukemic status. Understanding the biologic significance of soluble IL-2R in acute leukemia will be required.
Keywords: Soluble IL-2 receptor, Acute leukemia,
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