Korean J Hematol 2009; 44(4):
Published online December 30, 2009
https://doi.org/10.5045/kjh.2009.44.4.289
© The Korean Society of Hematology
김현수 김세형 김현정 이상철 배상병 김찬규 이규택 박성규 원종호 홍대식 박희숙 추은주
순천향대학교 의과대학 종양혈액내과학교실, 감염내과학교실
Myelodysplastic syndrome (MDS) is a heterogeneous group of disorders characterized by ineffective hematopoiesis, morphological dysplasia, peripheral blood cytopenias, and progressive bone marrow failure. The only proven curative treatment for MDS is hematopoietic stem cell transplantation. However, invasive fungal infection following hematopoietic stem cell transplantation has become the leading cause of death from infection. Therefore, transplant candidates with previous invasive fungal infection have often been excluded from the transplant program due to high risk of reactivation and associated death. We report on a case involving an MDS patient with complications from invasive aspergillosis who had shown no response to amphotericin-B. The patient underwent successfully unrelated allogeneic hematopoietic stem cell transplantation. (Korean J Hematol 2009;44:289-293.)
Keywords Myelodysplastic syndrome, Hematopoietic stem cell transplantation, Aspergillosis
Korean J Hematol 2009; 44(4): 289-293
Published online December 30, 2009 https://doi.org/10.5045/kjh.2009.44.4.289
Copyright © The Korean Society of Hematology.
김현수 김세형 김현정 이상철 배상병 김찬규 이규택 박성규 원종호 홍대식 박희숙 추은주
순천향대학교 의과대학 종양혈액내과학교실, 감염내과학교실
Hyun Su Kim, Se Hyung Kim, Hyun Jung Kim, Sang Cheol Lee, Sang Byung Bae, Chan Kyu Kim, Kyu Teak Lee, Seong Kyu Park, Jong Ho Won, Dae Sik Hong, Hee Sook Park, Eun Ju Choo
Departments of Hematology Oncology and Infection, Soonchunhyang University School of Medicine, Bucheon, Korea
Myelodysplastic syndrome (MDS) is a heterogeneous group of disorders characterized by ineffective hematopoiesis, morphological dysplasia, peripheral blood cytopenias, and progressive bone marrow failure. The only proven curative treatment for MDS is hematopoietic stem cell transplantation. However, invasive fungal infection following hematopoietic stem cell transplantation has become the leading cause of death from infection. Therefore, transplant candidates with previous invasive fungal infection have often been excluded from the transplant program due to high risk of reactivation and associated death. We report on a case involving an MDS patient with complications from invasive aspergillosis who had shown no response to amphotericin-B. The patient underwent successfully unrelated allogeneic hematopoietic stem cell transplantation. (Korean J Hematol 2009;44:289-293.)
Keywords: Myelodysplastic syndrome, Hematopoietic stem cell transplantation, Aspergillosis
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