Korean J Hematol 2008; 43(4):
Published online December 31, 2008
https://doi.org/10.5045/kjh.2008.43.4.247
© The Korean Society of Hematology
어완규 안규정 이우인 임성직 정종수
경희대학 의과대학 내과, 임상병리학
경희대학교 동서신의학병원 내과
We report here on a case of metachronous second primary non-Hodgkin's lymphoma (NHL) that was diagnosed 6 years after performing subtotal gastrectomy for treating early gastric cancer (EGC). The subtype analysis revealed mantle cell lymphoma (MCL) of the blastic variant with a leukemic presentation, which was composed of mixed small and medium-sized cells. The immunohistochemical staining for cyclin-D1 was positive. The cytogenetic study revealed t(4;6). In Korea, the risk of developing a second primary cancer following gastric cancer was reported to be less than 3.4%, and NHL comprised less than 6.3% of this second primary cancer. Furthermore, MCL represents about 2% of all lymphomas in Korea. To the best of our knowledge, this is the first report of metachronous primary MCL with a leukemic presentation following curative resection of EGC.
Keywords Gastric cancer, Metachronous second primary neoplasms, Mantle cell lymphoma, Leukemia
Korean J Hematol 2008; 43(4): 247-252
Published online December 31, 2008 https://doi.org/10.5045/kjh.2008.43.4.247
Copyright © The Korean Society of Hematology.
어완규 안규정 이우인 임성직 정종수
경희대학 의과대학 내과, 임상병리학
경희대학교 동서신의학병원 내과
Wan Kyu Eo, Kyu Jeung Ahn, Woo In Lee, Sung Jig Lim, Jong Soo Jeong
Departments of Internal Medicine, Laboratory Medicine, and Pathology, Kyung Hee University School of Medicine,
Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University, Seoul, Korea
We report here on a case of metachronous second primary non-Hodgkin's lymphoma (NHL) that was diagnosed 6 years after performing subtotal gastrectomy for treating early gastric cancer (EGC). The subtype analysis revealed mantle cell lymphoma (MCL) of the blastic variant with a leukemic presentation, which was composed of mixed small and medium-sized cells. The immunohistochemical staining for cyclin-D1 was positive. The cytogenetic study revealed t(4;6). In Korea, the risk of developing a second primary cancer following gastric cancer was reported to be less than 3.4%, and NHL comprised less than 6.3% of this second primary cancer. Furthermore, MCL represents about 2% of all lymphomas in Korea. To the best of our knowledge, this is the first report of metachronous primary MCL with a leukemic presentation following curative resection of EGC.
Keywords: Gastric cancer, Metachronous second primary neoplasms, Mantle cell lymphoma, Leukemia
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