Case Report
Korean J Hematol 2008; 43(3):
Published online September 30, 2008
https://doi.org/10.5045/kjh.2008.43.3.166
© The Korean Society of Hematology
전골수성 백혈병 환자에서 아트라 사용 후 발생한 신증후군 양상의 고립성 단백뇨증 1예
임성욱 이세련 서성례 안재숙 김여경 양덕환 이제중 김형준
전남대학 의과대학 내과
All-trans Retinoic Acid-induced Nephrotic-range Proteinuria in a Patient with Acute Promyelocytic Leukemia
All-trans retinoic acid (ATRA) is a potent differentiating agent for the treatment of acute promyelocytic leukemia (APL). Although ATRA is generally well-tolerated, some patients develop side effects, the most severe of which is ATRA syndrome. We report on a patient with APL who developed isolated nephrotic-range proteinuria during ATRA therapy for remission-induction. ATRA was discontinued and the proteinuria decreased significantly 5 days after dexamethasone treatment. The occurrence of isolated proteinuria during ATRA treatment is a rare adverse event
Keywords Proteinuria, Acute promyelocytic leukemia, All-trans retinoic acid
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Case Report
Korean J Hematol 2008; 43(3): 166-169
Published online September 30, 2008 https://doi.org/10.5045/kjh.2008.43.3.166
Copyright © The Korean Society of Hematology.
전골수성 백혈병 환자에서 아트라 사용 후 발생한 신증후군 양상의 고립성 단백뇨증 1예
임성욱 이세련 서성례 안재숙 김여경 양덕환 이제중 김형준
전남대학 의과대학 내과
All-trans Retinoic Acid-induced Nephrotic-range Proteinuria in a Patient with Acute Promyelocytic Leukemia
Seong Uk Lim, Se Ryeon Lee, Seong Rye Seo, Jae Sook Ahn, Yeo Kyeoung Kim, Deok Hwan Yang, Je Jung Lee, Hyeoung Joon Kim
Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea
Abstract
All-trans retinoic acid (ATRA) is a potent differentiating agent for the treatment of acute promyelocytic leukemia (APL). Although ATRA is generally well-tolerated, some patients develop side effects, the most severe of which is ATRA syndrome. We report on a patient with APL who developed isolated nephrotic-range proteinuria during ATRA therapy for remission-induction. ATRA was discontinued and the proteinuria decreased significantly 5 days after dexamethasone treatment. The occurrence of isolated proteinuria during ATRA treatment is a rare adverse event
Keywords: Proteinuria, Acute promyelocytic leukemia, All-trans retinoic acid
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