Korean J Hematol 2002; 37(4):
Published online December 31, 2002
© The Korean Society of Hematology
저용량의 Erythropoietin에 의존적인 혈액학적 반응을 보인 중증 재생불량성빈혈
서광운, 채의수, 성우진, 전석봉, 박만기, 김종광, 손상균, 이규보
경북대학교 의과대학 내과학교실,
경북대학교 의과대학 암연구소
Report of Two Patients with Severe Aplastic Anemia Who Showed Trilineage Hematologic Response to Low-dose Erythropoietin
Aplastic anemia is characterized by multilineage bone marrow failure resulting in pancytopenia. There is no effective therapy for patients with severe aplastic anemia who were refractory to immunosuppresive therapy including antithymocyte globulin (ATG) or relapsed after allogeneic bone marrow transplantation. We report hereby that two patients with severe aplastic anemia who were relapsed after immunosuppresive therapy with ATG and cyclosporine A were successfully treated with low dose erythropoietin.
Observed trilineage hematologic response was dependent on low dose erythropoietin therapy.
Keywords Aplastic anemia; Erythropoietin; Trilineage response;
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Korean J Hematol 2002; 37(4): 282-286
Published online December 31, 2002
Copyright © The Korean Society of Hematology.
저용량의 Erythropoietin에 의존적인 혈액학적 반응을 보인 중증 재생불량성빈혈
서광운, 채의수, 성우진, 전석봉, 박만기, 김종광, 손상균, 이규보
경북대학교 의과대학 내과학교실,
경북대학교 의과대학 암연구소
Report of Two Patients with Severe Aplastic Anemia Who Showed Trilineage Hematologic Response to Low-dose Erythropoietin
Kwang Woon Seo, Wee Soo Chae, Suk Bong Jeon, Woo Jin Sung, Man Gi Park, Jong Gwang Kim, Sang Kyun Sohn, Kyu Bo Lee
Department of Internal Medicine, Cancer Research Institute, Kyungpook National University, School of Medicine, Daegu, Korea
Abstract
Aplastic anemia is characterized by multilineage bone marrow failure resulting in pancytopenia. There is no effective therapy for patients with severe aplastic anemia who were refractory to immunosuppresive therapy including antithymocyte globulin (ATG) or relapsed after allogeneic bone marrow transplantation. We report hereby that two patients with severe aplastic anemia who were relapsed after immunosuppresive therapy with ATG and cyclosporine A were successfully treated with low dose erythropoietin.
Observed trilineage hematologic response was dependent on low dose erythropoietin therapy.
Keywords: Aplastic anemia, Erythropoietin, Trilineage response,
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