Korean J Hematol 2002; 37(4):
Published online December 31, 2002
© The Korean Society of Hematology
한국인 급성골수성백혈병과 골수이형성증후군에서 Glutathione S-Transferase (GST) 유전자 결손분석
우희연, 이경아, 홍영준, 박효순, 김선희
원자력병원 진단검사의학과,
성균관의대 진단검사의학과
Glutathione S-Transferase (GST) Gene Deletions in Korean Patients with Acute Myeloid Leukemia or Myelodysplastic Syndrome
Background : There have been many studies on the association between the glutathione S- transferase (GST) genotype and the susceptibility to acute myeloid leukemia (AML)/myelodysplastic syndrome (MDS) and the results are still controversial. We tested whether the homozygous null genotype of GST mu 1 (GSTM1) and GST theta 1 (GSTT1) genes influences the risk for MDS and AML.
Methods :
We analyzed bone marrow DNA samples from 54 patients with AML or MDS (14 de novo AML, 7 secondary AML, and 33 MDS) and peripheral blood DNA samples from 75 cancer-free controls. The GSTM1 and GSTT1 genotypes were analyzed by multiplex polymerase chain reaction (PCR).
Results : The frequencies of GSTM1 null and GSTT1 null were not significantly increased in AML/MDS cases compared with those in controls.
Conclusion : Our data suggest that GSTM1 and GSTT1 null genotypes may not predispose to AML/MDS in Korean population.
Keywords Glutathione S-transferase (GST) gene deletion; Acute myeoloid leukemia; Myelodysplastic syndrome;
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Korean J Hematol 2002; 37(4): 265-269
Published online December 31, 2002
Copyright © The Korean Society of Hematology.
한국인 급성골수성백혈병과 골수이형성증후군에서 Glutathione S-Transferase (GST) 유전자 결손분석
우희연, 이경아, 홍영준, 박효순, 김선희
원자력병원 진단검사의학과,
성균관의대 진단검사의학과
Glutathione S-Transferase (GST) Gene Deletions in Korean Patients with Acute Myeloid Leukemia or Myelodysplastic Syndrome
Hee Yeon Woo, Kyung A Lee, Young Jun Hong, Hyo Soon Park, Sun Hee Kim
Department of Laboratory Medicine, Sungkyunwan University School of Medicine, Seoul, Korea
Department of Laboratory Medicine, Korea Cancer Center Hospital, Seoul, Korea
Abstract
Background : There have been many studies on the association between the glutathione S- transferase (GST) genotype and the susceptibility to acute myeloid leukemia (AML)/myelodysplastic syndrome (MDS) and the results are still controversial. We tested whether the homozygous null genotype of GST mu 1 (GSTM1) and GST theta 1 (GSTT1) genes influences the risk for MDS and AML.
Methods :
We analyzed bone marrow DNA samples from 54 patients with AML or MDS (14 de novo AML, 7 secondary AML, and 33 MDS) and peripheral blood DNA samples from 75 cancer-free controls. The GSTM1 and GSTT1 genotypes were analyzed by multiplex polymerase chain reaction (PCR).
Results : The frequencies of GSTM1 null and GSTT1 null were not significantly increased in AML/MDS cases compared with those in controls.
Conclusion : Our data suggest that GSTM1 and GSTT1 null genotypes may not predispose to AML/MDS in Korean population.
Keywords: Glutathione S-transferase (GST) gene deletion, Acute myeoloid leukemia, Myelodysplastic syndrome,
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