Korean J Hematol 2002; 37(2):
Published online June 30, 2002
© The Korean Society of Hematology
골수 침윤을 동반한 간비장 γδ T세포림프종 1례
이성규, 우희연, 박규은, 김선희, 이홍기, 고영혜
성균관대학교 의과대학 임상병리학교실,
성균관대학교 의과대학 내과학교실,
성균관대학교 의과대학 진단병리학교실
A Case of Bone Marrow Involvement of Hepatosplenic γδ T-Cell Lymphoma
Hepatosplenic γδ T-cell lymphoma is a rare histologic type of peripheral T-cell lymphomas, clinically characterized by predominant involvement of liver and spleen, no or little adenopathy, and an often aggressive course. We report a case of bone marrow involvement of hepatosplenic γδ T-cell lymphoma in a 21- year-old woman who presented with fever, anemia, thrombocytopenia, and hepatosplenomegaly. A lymphoma was found subsequently by bone marrow biopsy and computed tomography scan of
the abdomen and pelvis. Immunologic characterization of lymphoma cells in bone marrow revealed positivity for CD2, CD3, and CD16/56, and negativity for CD4, CD5, CD7, CD8, CD34, and terminal deoxynucleotidyl transferase (TdT). Conventional cytogenetic studies revealed the presence of isochromosome 7q. Using the PCR-SSCP technique, monoclonal gene rearrangement of the T-cell receptor gamma chain was demonstrated. Thus, we could make a confirmatory diagnosis as hepatosplenic γδ T-cell lymphoma.
Keywords Hepatosplenic; γδ T-cell; Peripheral T-cell lymphoma; Isochromosome 7q; T-cell receptor;
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Korean J Hematol 2002; 37(2): 134-137
Published online June 30, 2002
Copyright © The Korean Society of Hematology.
골수 침윤을 동반한 간비장 γδ T세포림프종 1례
이성규, 우희연, 박규은, 김선희, 이홍기, 고영혜
성균관대학교 의과대학 임상병리학교실,
성균관대학교 의과대학 내과학교실,
성균관대학교 의과대학 진단병리학교실
A Case of Bone Marrow Involvement of Hepatosplenic γδ T-Cell Lymphoma
Seong Kyu Lee, Hee Yeon Woo, Quehn Park, Sun Hee Kim, Hong Gee Lee, Young Hyeh Ko
Department of Clinical Pathology, Internal Medicine, Diagnostic Pathology, Sungkyunkwan University School of Medicine, Seoul, Korea
Abstract
Hepatosplenic γδ T-cell lymphoma is a rare histologic type of peripheral T-cell lymphomas, clinically characterized by predominant involvement of liver and spleen, no or little adenopathy, and an often aggressive course. We report a case of bone marrow involvement of hepatosplenic γδ T-cell lymphoma in a 21- year-old woman who presented with fever, anemia, thrombocytopenia, and hepatosplenomegaly. A lymphoma was found subsequently by bone marrow biopsy and computed tomography scan of
the abdomen and pelvis. Immunologic characterization of lymphoma cells in bone marrow revealed positivity for CD2, CD3, and CD16/56, and negativity for CD4, CD5, CD7, CD8, CD34, and terminal deoxynucleotidyl transferase (TdT). Conventional cytogenetic studies revealed the presence of isochromosome 7q. Using the PCR-SSCP technique, monoclonal gene rearrangement of the T-cell receptor gamma chain was demonstrated. Thus, we could make a confirmatory diagnosis as hepatosplenic γδ T-cell lymphoma.
Keywords: Hepatosplenic, γδ T-cell, Peripheral T-cell lymphoma, Isochromosome 7q, T-cell receptor,
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