Korean J Hematol 2002; 37(1):
Published online March 31, 2002
© The Korean Society of Hematology
B형 만성림프구성백혈병 환자에 동반된 순수적혈구형성부전증 1례
이재련, 강희정, 오현아, 이구, 이경희, 현명수, 류헌모
영남대학교 의과대학 혈액종양내과학교실,
가톨릭대학교 의과대학 혈액종양내과학교실
A Case of Pure Red Cell Aplasia Associated with B-cell Chronic Lymphocytic Leukemia
Pure red cell aplasia (PRCA) si a rare disorder, which is characterized by severe anemia associated with reticulocytopenia and absence of erythroid precursor cells in the bone marrow. Recently we experienced a patient with B-cell chronic lymphocytic leukemia associated with PRCA, which was successfully treated with prednisone. A 50-year-old man was admitted because of lymphocytosis. The leukocyte count was 26,800/㎕ with 82% abnormal mature lymphocytes. Neither anemia nor thrombocytopenia was
present. Many abnormal lymphocytes and erythroblasts were seen in the bone marrow. The surface markers of these cells were positive for CD5, CD19, CD20, CD22, and surface immunoglobulin. The patient was diagnosed of B-CLL in Binet-Rai stage A (Ⅱ), and was treated with chlorambucil. Six months later, severe anemia (hemoglobin 5.9g/㎗) with reticulocytopenia developed. In the bone marrow at that time, neutrophils and megakaryocytes besides leukemic cells were preserved, but marked decrease of erythroblasts, a pattern of PRCA was observed. After one-month's hemoglobin reached 10.9g/㎗, and he needed no further transfusion.
Keywords Pure red cell aplasia; Chronic lymphocytic leukemia;
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Korean J Hematol 2002; 37(1): 60-64
Published online March 31, 2002
Copyright © The Korean Society of Hematology.
B형 만성림프구성백혈병 환자에 동반된 순수적혈구형성부전증 1례
이재련, 강희정, 오현아, 이구, 이경희, 현명수, 류헌모
영남대학교 의과대학 혈액종양내과학교실,
가톨릭대학교 의과대학 혈액종양내과학교실
A Case of Pure Red Cell Aplasia Associated with B-cell Chronic Lymphocytic Leukemia
Jae Lyun Lee, Hee Jung Kang, Hyun Ah Oh, Gu Lee, Kyung Hee Lee, Myung Soo Hyun, Hyun Mo Ryoo
Department of Internal Medicine, College of Medicine, Yeungnam University
The Catholic University of Korea, Daegu, Korea
Abstract
Pure red cell aplasia (PRCA) si a rare disorder, which is characterized by severe anemia associated with reticulocytopenia and absence of erythroid precursor cells in the bone marrow. Recently we experienced a patient with B-cell chronic lymphocytic leukemia associated with PRCA, which was successfully treated with prednisone. A 50-year-old man was admitted because of lymphocytosis. The leukocyte count was 26,800/㎕ with 82% abnormal mature lymphocytes. Neither anemia nor thrombocytopenia was
present. Many abnormal lymphocytes and erythroblasts were seen in the bone marrow. The surface markers of these cells were positive for CD5, CD19, CD20, CD22, and surface immunoglobulin. The patient was diagnosed of B-CLL in Binet-Rai stage A (Ⅱ), and was treated with chlorambucil. Six months later, severe anemia (hemoglobin 5.9g/㎗) with reticulocytopenia developed. In the bone marrow at that time, neutrophils and megakaryocytes besides leukemic cells were preserved, but marked decrease of erythroblasts, a pattern of PRCA was observed. After one-month's hemoglobin reached 10.9g/㎗, and he needed no further transfusion.
Keywords: Pure red cell aplasia, Chronic lymphocytic leukemia,
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